Protective effect of taxifolin in the prevention of cardiac tissue damage in liver ischemia and reperfusion injury: Experimental study

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dc.authorid0000-0001-7203-2288en_US
dc.authorid0009-0009-6611-088Xen_US
dc.authorid0000-0001-9843-6301en_US
dc.authorid0000-0002-3161-0923en_US
dc.authorid0000-0002-6265-948Xen_US
dc.authorid0000-0002-1190-6129en_US
dc.authorid0000-0002-5648-6498en_US
dc.contributor.authorBilge, Hüseyin
dc.contributor.authorYıldızhan, İbrahim
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorAday, Ulaş
dc.contributor.authorBaşol, Ömer
dc.contributor.authorÇiçekçi, Kadriye
dc.contributor.authorYıldızhan, Eda
dc.date.accessioned2023-11-30T06:14:00Z
dc.date.available2023-11-30T06:14:00Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractAim: Liver ischemia and reperfusion (I/R) is a serious, irreversible health problem in clinical practice. Taxifolin (Tax) is an easy to obtain and use agent found in maritime pine bark, Douglas fir bark and Siberian larch wood. In this study, we examined the protective efficacy of Taxifolin in the correction of cardiac tissue damage that may develop in liver I/R damage. Methods: In our study, a total of 28 Wistar Albino rats, 8-10 weeks old, weighing 250-300 grams, were used. Group 1 (n=7): control group, Group 2 (n=7): Tax group with 50 mg/kg dose orally for 3 weeks, Group 3 (n=7): Liver I/R group for 30 minutes ischemia and 120 minutes of reperfusion were performed. Group 4 (n=7): Tax+Liver I/R group. Results: In our study, MDA analysis was performed to evaluate oxidative stress. In the statistical analysis of MDA values, we observed that there was a statistically significant difference between the serum MDA values of the Tax group and the Tax+Liver I/R group, and the MDA level of the Tax group was lower (p<0.05). In myocyte damage scoring, we observed that the liver I/R group had the highest damage score, while the damage score of the Tax+Liver I/R group was significantly lower than the I/R group (p<0.05). Conclusion: As a result of our study, we observed that there was an increase in serum MDA levels as a result of liver I/R and histopathological changes occurred in the heart tissue. However, Taxifolin has been successful in ameliorating this situation.en_US
dc.identifier.citationBilge, H., Yıldızhan, İ., Ülger, B. V., Aday, U., Başol, Ö., Çiçekçi K. ve diğerleri. (2023). Protective effect of taxifolin in the prevention of cardiac tissue damage in liver ischemia and reperfusion injury: Experimental study. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(2), 272-275.en_US
dc.identifier.doi10.36516/jocass.1300968
dc.identifier.endpage275en_US
dc.identifier.issn2667-498X
dc.identifier.issue2en_US
dc.identifier.startpage272en_US
dc.identifier.trdizinid1197813
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197813
dc.identifier.urihttps://hdl.handle.net/11468/13065
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1197813
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÜlger, Burak Veli
dc.institutionauthorAday, Ulaş
dc.institutionauthorÇiçekçi, Kadriye
dc.institutionauthorYıldızhan, Eda
dc.language.isoenen_US
dc.publisherMerthan Tunayen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTaxifolinen_US
dc.subjectOxidative stressen_US
dc.subjectLiver ischemia and reperfusionen_US
dc.subjectHearten_US
dc.titleProtective effect of taxifolin in the prevention of cardiac tissue damage in liver ischemia and reperfusion injury: Experimental studyen_US
dc.titleProtective effect of taxifolin in the prevention of cardiac tissue damage in liver ischemia and reperfusion injury: Experimental study
dc.typeArticleen_US

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