Investigation of Cuckoo-Pint's (Arum maculatum) phytochemistry, in vitro antioxidant potential, enzyme inhibition, and antimicrobial activity

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0001-5993-1668en_US
dc.contributor.authorAslan, Kübra
dc.contributor.authorKelle, Kader
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorKopar, Emre Erden
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2024-11-08T06:53:28Z
dc.date.available2024-11-08T06:53:28Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractArum maculatum, cuckoo-pint in folk linguistics, is a poisonous but medicinal plant with tremendous properties that need investigation. This study subjected cuckoo-pint's parts to in vitro antioxidant, enzyme inhibition, and antimicrobial susceptibility testing to investigate its biological activity. Further, phytochemistry was analyzed by both LC–MS/MS and total phenol, flavonoid, saponin, and reducing sugar content determination assays. Antioxidant activities were determined by Fe3+, Cu2+, Fe3+-TPTZ metal-reducing ability, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. According to the results, seeds and berries have remarkable metal-reducing and radical-scavenging effects as natural and synthetic analogs such as ascorbic acid, butylated hydroxyanisole, butylated hydroxytoluene, trolox, and α-tocopherol. Inhibition studies over human carbonic anhydrase II (hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-amylase were performed, and IC50 values were determined for each enzyme inhibition. According to the results, the cuckoo-pint seeds inhibited the AChE, BChE, and hCA II activity with greater IC50 values than reference inhibitors. Antimicrobial activity over pan-resistant strains was achieved for each strain with the extracts, at least 20 mm zone diameter was obtained with the lowest concentrations. LC–MS/MS results revealed 24 bioactive metabolites associated with the extracts’ biological activity. Notably, quinic acid and epicatechin correlated with cardioprotective, neuroprotective, antioxidant, and antidiabetic activity.en_US
dc.identifier.citationAslan, K., Kelle, K., Yılmaz, M. A., Kopar, E. E. ve Gülçin, İ. (2024). Investigation of Cuckoo-Pint's (Arum maculatum) phytochemistry, in vitro antioxidant potential, enzyme inhibition, and antimicrobial activity. ChemistrySelect, 9(37), 1-13.en_US
dc.identifier.endpage13en_US
dc.identifier.issn2365-6549
dc.identifier.issue37en_US
dc.identifier.scopus2-s2.0-85205324086
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202403588
dc.identifier.urihttps://hdl.handle.net/11468/28934
dc.identifier.volume9en_US
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofChemistrySelect
dc.relation.isversionof10.1002/slct.202403588en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectArum maculatumen_US
dc.subjectCuckoo-pinten_US
dc.subjectEnzyme inhibitionen_US
dc.titleInvestigation of Cuckoo-Pint's (Arum maculatum) phytochemistry, in vitro antioxidant potential, enzyme inhibition, and antimicrobial activityen_US
dc.titleInvestigation of Cuckoo-Pint's (Arum maculatum) phytochemistry, in vitro antioxidant potential, enzyme inhibition, and antimicrobial activity
dc.typeArticleen_US

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