Endothelin-1 and APAF-1 Expression in the Umbilical Cord of Placenta Previa Cases

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dc.contributor.authorTaşin C.
dc.contributor.authorErmiş I.S.
dc.contributor.authorDeveci E.
dc.date.accessioned2024-04-24T18:46:35Z
dc.date.available2024-04-24T18:46:35Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the changes occurring in the umbilical cord of abnormally located placenta previa cases histopathologically and immunohistochemically, together with the clinical data of inflammation and angiogenetic process. STUDY DESIGN: Ten normotensive umbilical cords and 10 placenta previa umbilical cords (a total of 20 umbilical cords) were processed for routine histological tissue processing. The biochemical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and APAF-1? and endothelin-1 (ET-1) immunostaining. RESULTS: Significant differences were observed in the comparison of the clinical data of placenta previa and normotensive cases. In the histopathological examination, increased inflammation, cell degeneration, and hyperplasia in endothelial cells were observed in the placenta previa group. It was observed that ET-1 expression and APAF-1 expression in placenta previa umbilical cord increased in endothelial cells and fibroblast cells as compared to the control group. CONCLUSION: It is thought that it accelerates the pro-apoptotic process due to the development of inflammation in the endothelium, muscle, connective tissue cells, and amniotic epithelium in the umbilical cord as a result of placenta previa, and it will affect the contractile structure and angiogenetic development in the umbilical cord and make a negative contribution to the nutrition of the fetus. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage445en_US
dc.identifier.issn2578-742X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85129291916
dc.identifier.scopusqualityQ4
dc.identifier.startpage439en_US
dc.identifier.urihttps://hdl.handle.net/11468/25253
dc.identifier.volume43en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApaf-1en_US
dc.subjectApoptotic Protease Activating Factor-1en_US
dc.subjectEndothelin-1en_US
dc.subjectPlacenta Previaen_US
dc.subjectUmbilical Corden_US
dc.titleEndothelin-1 and APAF-1 Expression in the Umbilical Cord of Placenta Previa Casesen_US
dc.titleEndothelin-1 and APAF-1 Expression in the Umbilical Cord of Placenta Previa Cases
dc.typeArticleen_US

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