The Role of Central Nervous System in the Pathogenesis of Restless Legs Syndrome

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dc.contributor.authorAcar, Suat
dc.contributor.authorApak, Ismail
dc.contributor.authorTamam, Yusuf
dc.contributor.authorGencer, Ahmet Murat
dc.date.accessioned2024-04-24T17:44:53Z
dc.date.available2024-04-24T17:44:53Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractRestless legs syndrome is a neurological disorder of the legs characterized by spontaneous movements and paresthesia which appear at rest or sleep and are relieved movements. The studies searching for the ethiopathogenesis of the syndrome showed the role of the central nervous system. According to electrophysiological and neuroimaging studies, abnormalities involving corticothalamospinal tracts which contribute locomotor system physiology have been determined. Recent studies showed dysfunction of the central dopaminergic systeni and symptoms could be ameliorated by dopaminergic drugs. Although central circadian factors of the disorder were suspected to be responsible for ethiopathogenesis, most factors remain to be elucidated. Uncertain aspects of the disorder may be explained more definitely after the researches focus on sensory-motor symptoms organized in central structures, participating neuron types, mediating neurotransmitters and central control mechanisms.en_US
dc.identifier.endpage102en_US
dc.identifier.issn1018-8681
dc.identifier.issn1309-5749
dc.identifier.issue2en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://hdl.handle.net/11468/22330
dc.identifier.volume19en_US
dc.identifier.wosWOS:000421403800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofDusunen Adam-Journal of Psychiatry and Neurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRestless Legs Syndromeen_US
dc.subjectCentral Nervous Systemen_US
dc.subjectDopaminergic Systemen_US
dc.subjectCircadian Factorsen_US
dc.titleThe Role of Central Nervous System in the Pathogenesis of Restless Legs Syndromeen_US
dc.titleThe Role of Central Nervous System in the Pathogenesis of Restless Legs Syndrome
dc.typeReview Articleen_US

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