Prolonged Simvastatin Treatment Provided a Decrease in Apoptotic, Inflammatory, and Oxidative Stress Markers in Ischemia-Reperfusion-Induced Acute Kidney Injury Model of Rats

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dc.contributor.authorKafkasli, Alper
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.date.accessioned2024-04-24T17:47:26Z
dc.date.available2024-04-24T17:47:26Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Ischemia-reperfusion (I/R) leads to reactive oxygen species formation and cell death in kidney tissue with injury and organ transplantation. Simvastatin (SIM) is an antioxidant, anti-inflammatory, and anticoagulant agent. Alterations in I/R-induced acute kidney injury model with SIM treatment were analyzed. STUDY DESIGN: Wistar rats (n=28) were grouped into Sham, Ischemia, I/R, and I/R+ SIM treated. Left rat kidney renal vessels were clamped for 60 minutes for ischemia, and the I/R group had 6 hours of reperfusion. 10 mg/kg SIM was given orally for 28 days. MDA, GSH, and MPO were analyzed. Kidney tissues were paraffin embedded, and primary antibodies TNF-alpha and caspase-3 were applied for immunohistochemistry. RESULTS: In the I/R group, intense inflammatory cell infiltration around the vessels and necrosis in the glomerular structures were observed. In the treated group, proximal and distal tubular cells were found to be close to normal. Immunoexpression of caspase-3 in the ischemia group was positive in degenerative glomeruli. In the treated group, TNF-alpha expression was negative in the glomerular structures. MDA and MPO levels were significantly increased in ischemia and I/R. CONCLUSION: We suggest that SIM treatment improved kidney tissue structure and function in a model of I/R injury.en_US
dc.identifier.endpage173en_US
dc.identifier.issn0884-6812
dc.identifier.issue4en_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://hdl.handle.net/11468/22476
dc.identifier.volume43en_US
dc.identifier.wosWOS:000708937900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-3en_US
dc.subjectImmunohistochemistryen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectKidneyen_US
dc.subjectMpoen_US
dc.subjectSimvastatinen_US
dc.titleProlonged Simvastatin Treatment Provided a Decrease in Apoptotic, Inflammatory, and Oxidative Stress Markers in Ischemia-Reperfusion-Induced Acute Kidney Injury Model of Ratsen_US
dc.titleProlonged Simvastatin Treatment Provided a Decrease in Apoptotic, Inflammatory, and Oxidative Stress Markers in Ischemia-Reperfusion-Induced Acute Kidney Injury Model of Rats
dc.typeArticleen_US

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