The evaluation of relationship between plasma asymmetric dimethylarginine (ADMA) and aortic stiffness in patients with systemic sclerosis

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dc.contributor.authorAritürk Z.
dc.contributor.authorDağ Ş.
dc.contributor.authorAli Elbey M.
dc.contributor.authorKaya H.
dc.contributor.authorErta F.
dc.contributor.authorBozkurt M.
dc.contributor.authorÇevik R.
dc.date.accessioned2024-04-24T18:43:41Z
dc.date.available2024-04-24T18:43:41Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis. Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28 females, mean age 40.7±11.6) and 30 healthy subjects (27 females, mean age 40.6±13). Aortic stiffness was determined with echocardiography. Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53±0.13?mol/l compared with 0.46±0.15 ?mol/l for control group. Systolic blood pressure, pulse pressure and aortic 'strain' were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic 'strain'. Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort's elastic structure (aortic 'strain', distensibility, and aortic stiffness index).en_US
dc.identifier.endpage115en_US
dc.identifier.issn1305-2381
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84891666055en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://hdl.handle.net/11468/24295
dc.identifier.volume9en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAortaen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectSystemic Sclerosisen_US
dc.titleThe evaluation of relationship between plasma asymmetric dimethylarginine (ADMA) and aortic stiffness in patients with systemic sclerosisen_US
dc.title.alternativeSistemik sklerozu olan hastalarda aortun elastik yapi{dotless}si{dotless} ile plazma asimetrik dimetilarginin (ADMA) arasi{dotless}ndaki ilişkinin değerlendirilmesien_US
dc.typeArticleen_US

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