The protective effect of ellagic acid against renal ischemia-reperfusion injury in male rats

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dc.contributor.authorBozkurt Y.
dc.contributor.authorFirat U.
dc.contributor.authorAtar M.
dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorPembegul N.
dc.contributor.authorSoylemez H.
dc.contributor.authorYuksel H.
dc.date.accessioned2024-04-24T17:58:33Z
dc.date.available2024-04-24T17:58:33Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia-reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.en_US
dc.identifier.doi10.9775/kvfd.2012.6517
dc.identifier.endpage828en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84864094765en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage823en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2012.6517
dc.identifier.urihttps://hdl.handle.net/11468/23983
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherVeteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEllagic Aciden_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectKidneyen_US
dc.subjectRaten_US
dc.titleThe protective effect of ellagic acid against renal ischemia-reperfusion injury in male ratsen_US
dc.title.alternativeErkek Ratlarda Renal İskemi-Reperfüzyon Hasarına Karşı Elajik Asitin Koruyucu Etkisien_US
dc.typeArticleen_US

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