Synthesis of Thioglycolic Acid-Modified Molybdenum Disulfide Nanosheets for Electrochemical Sensing and Its Application in Molnupiravir Detection

Basit Öğe Kaydı
dc.authoridATES, Ali Kemal/0000-0002-5846-4436
dc.contributor.authorAtes, Ali Kemal
dc.contributor.authorEr, Engin
dc.date.accessioned2025-02-22T14:08:51Z
dc.date.available2025-02-22T14:08:51Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the modern world, population growth, industrialization, and lifestyle changes have led to a rise in existing and new diseases, increasing global drug consumption. Proper pharmaceutical dosage is vital since drugs are only effective within specific concentration ranges. Therefore, developing reliable analytical methods for drug analysis in pharmaceuticals and biological samples is essential. Electroanalytical methods are particularly advantageous due to their low cost, ease of use, and rapid response. This study introduces a highly sensitive electrochemical sensor based on thioglycolic acid (TA)-decorated metallic phase molybdenum disulfide (MP-MoS2) nanosheets for the selective detection of molnupiravir (MOL), an antiviral drug used in Covid-19 treatment. The TA@MP-MoS2 nanomaterial was characterized using FTIR, TEM, and EIS. Screen-printed carbon electrodes (SPCE) were modified with TA@MP-MoS2 nanosheets to evaluate their electro-chemical and catalytic behaviours towards MOL by cyclic voltammetry (CV) and square wave voltammetry (SWV). The sensor displayed a well-defined electro-oxidation signal for MOL at 0.534 V, with the linear responses in two concentration ranges: 0.50-3.40 mu M and 3.40-9.55 mu M, and a low detection limit of 22.6 nM. The proposed design that has promising results could be an alternative strategy to fabricate the sensitive sensor for the detection of antiviral agents in real samples.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Unit [ECZACILIK.23.001]; University Scientific Research Projects Coordination [TSA-2023-2751]en_US
dc.description.sponsorshipA.K.A. thanks to Dicle University Scientific Research Projects Coordination Unit for financial support with the project number of ECZACILIK.23.001. E.E. also thanks Ankara University Scientific Research Projects Coordination Unit for financial support under grant TSA-2023-2751.en_US
dc.identifier.doi10.1149/1945-7111/ad851e
dc.identifier.issn0013-4651
dc.identifier.issn1945-7111
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1149/1945-7111/ad851e
dc.identifier.urihttps://hdl.handle.net/11468/29677
dc.identifier.volume171en_US
dc.identifier.wosWOS:001339053300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherElectrochemical Soc Incen_US
dc.relation.ispartofJournal of the Electrochemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectMoS2en_US
dc.subjectthioglycolic aciden_US
dc.subjectmolnupiraviren_US
dc.subjectelectrochemical sensoren_US
dc.subjectCovid-19en_US
dc.titleSynthesis of Thioglycolic Acid-Modified Molybdenum Disulfide Nanosheets for Electrochemical Sensing and Its Application in Molnupiravir Detectionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu