EFFECTS OF MANGANESE ETHYLENE-BIS-DITHIOCARBAMATE (MANEB) ON RAT NASAL RESPIRATORY MUCOSA

Basit Öğe Kaydı
dc.contributor.authorDeveci, E.
dc.contributor.authorYorgancilar, E.
dc.contributor.authorEkinci, C.
dc.contributor.authorKoparal, M.
dc.contributor.authorAkkus, Z.
dc.contributor.authorYavuz, D.
dc.date.accessioned2024-04-24T17:44:43Z
dc.date.available2024-04-24T17:44:43Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractManeb (Mn-ethylene(bis)dithiocarbamate is a dithiocarbamate pesticides. It is a fungicide pesticide used in the control of mildew disease on certain crops. In general, dithiocarbamates are considered chemicals of low toxicity for humans. However, the effects of maneb in humans are diverse. It has some effects to humans via absorption through skin and respiratory system. The nasal mucosa is the first part of the airways in contact with the environment and toxic agents. The aim of this study was todetermine the histopathological effects of numb on nasal mucosa. In experimental group, the maneb was administered with inhalation to 10 male Wistar-Albino rats for five days a week. The control group (n=10) received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group,microscopic examination of nasal respiratory mucosa revealed; Hypertrophy of epithelial cells and goblet cells, increasing of mucus secretion, decreasing in sizes of cilia and flattening of the cells near the basement membrane and apoptotic cells in the degenerated respiratory epithelial cells, detected a mild inflammatory reaction and a vascular dilatation in the connective tissue. All changes were statistically significant. In control group of 10 rats no significant histopathologic lesions were found. As a result, our study, maneb is potentially toxic agent to respiratory mucosa.en_US
dc.identifier.endpage878en_US
dc.identifier.issn0393-6384
dc.identifier.issue4en_US
dc.identifier.startpage875en_US
dc.identifier.urihttps://hdl.handle.net/11468/22248
dc.identifier.volume29en_US
dc.identifier.wosWOS:000330151200045
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectManeben_US
dc.subjectNasalen_US
dc.subjectMucosaen_US
dc.subjectRespiratoryen_US
dc.subjectRaten_US
dc.titleEFFECTS OF MANGANESE ETHYLENE-BIS-DITHIOCARBAMATE (MANEB) ON RAT NASAL RESPIRATORY MUCOSAen_US
dc.titleEFFECTS OF MANGANESE ETHYLENE-BIS-DITHIOCARBAMATE (MANEB) ON RAT NASAL RESPIRATORY MUCOSA
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu