Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia

Basit Öğe Kaydı
dc.authorid0000-0002-4337-9327en_US
dc.contributor.authorVlahopoulos, Spiros A.
dc.contributor.authorVarışli, Lokman
dc.contributor.authorZoumpourlis, Panagiotis
dc.contributor.authorSpandidos, Demetrios A.
dc.contributor.authorZoumpourlis, Vassilis
dc.date.accessioned2024-11-19T13:22:55Z
dc.date.available2024-11-19T13:22:55Z
dc.date.issued30.10.2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractAldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a member of the aldehyde dehydrogenase gene subfamily that encode enzymes with the ability to oxidize retinaldehyde. It was recently shown that high ALDH1A1 RNA abundance correlates with a poor prognosis in acute myeloid leukemia (AML). AML is a hematopoietic malignancy associated with high morbidity and mortality rates. Although there are a number of agents that inhibit ALDH activity, it would be crucial to develop methodologies for adjustable genetic interference, which would permit interventions on several oncogenic pathways in parallel. Intervention in multiple oncogenic pathways is theoretically possible with microRNAs (miRNAs or miRs), a class of small non‑coding RNAs that have emerged as key regulators of gene expression in AML. A number of miRNAs have shown the ability to interfere with ALDH1A1 gene expression directly in solid tumor cells, and these miRNAs can be evaluated in AML model systems. There are indications that a few of these miRNAs actually do have an association with AML disease course, rendering them a promising target for genetic intervention in AML cells.en_US
dc.identifier.citationVlahopoulos, S.A., Varışli, L., Zoumpourlis, P., Spandidos, D.A. ve Zoumpourlis, V. (2024). Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia. International Journal of Oncology, 65(6), 115.en_US
dc.identifier.endpage11en_US
dc.identifier.issn1019-6439
dc.identifier.issn1791-2423
dc.identifier.issue6en_US
dc.identifier.pmidPMID: 39513593
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.spandidos-publications.com/ijo/65/6/115
dc.identifier.urihttps://hdl.handle.net/11468/29050
dc.identifier.volume65en_US
dc.indekslendigikaynakPubMed
dc.institutionauthorVarışli, Lokman
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.relation.ispartofInternational Journal of Oncology
dc.relation.isversionof10.3892/ijo.2024.5703en_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute myeloid leukemiaen_US
dc.subjectAldehyde dehydrogenaseen_US
dc.subjectAldehyde dehydrogenase 1 family member A1en_US
dc.subjectmicroRNA‑140‑5pen_US
dc.subjectmicroRNA‑181a‑5pen_US
dc.subjectmicro‑RNAen_US
dc.titleInvestigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemiaen_US
dc.titleInvestigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
ijo_65_6_5703_PDF.pdf
Boyut:
1.75 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu