Ethyl Pyruvate Prevents Ischemia Reperfusion Injury in Isolated Perfused Rat Heart

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dc.contributor.authorAkkoc, Hasan
dc.contributor.authorTunik, Selcuk
dc.contributor.authorKelle, Ilker
dc.contributor.authorGurkan, Ahmet
dc.contributor.authorErdogmus, Zeynep
dc.contributor.authorSimsek, Selda
dc.contributor.authorErdinc, Meral
dc.date.accessioned2024-04-24T17:44:21Z
dc.date.available2024-04-24T17:44:21Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the protective effect of ethyl pyruvate (EP) against ischemia reperfusion (I/R) injury in isolated rat heart. Male Sprague-Dawley rats were divided into three groups (n = 8); Group 1: Control group, Group 2: I/R, Group 3: I/R+EP. Ischemia was produced for 30 min by blocking the perfusion with Krebs Henseleit solution and it was followed by reperfusion for 60 min. In group 3, EP (2 mmol/L) was added into Krebs Henseleit solution after stabilization period. EP did not change the number of a-smooth muscle actin positive vessels and expression of Bcl-2 and desmin. Treatment with EP significantly reduced I/R induced extension in infarct size (p < 0.001) and release of lactate dehidrogenase (p < 0.001) and creatine phosphokinase (p < 0.05). Myocardial I/R injury significantly increased oxidative stress index and malondialdehyde, total oxidant status levels and significantly decreased paraoxonase actvity and total antioxidant status (p < 0.05). On the other hand, alterations in these biochemical indices due to I/R injury were attenuated by EP treatment (p < 0.01). These results show that ethyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart.en_US
dc.identifier.endpage370en_US
dc.identifier.issn0326-2383
dc.identifier.issue3en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://hdl.handle.net/11468/21950
dc.identifier.volume32en_US
dc.identifier.wosWOS:000323533600009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectEthyl Pyruvateen_US
dc.subjectInfarct Sizeen_US
dc.subjectMyocardial Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.titleEthyl Pyruvate Prevents Ischemia Reperfusion Injury in Isolated Perfused Rat Hearten_US
dc.titleEthyl Pyruvate Prevents Ischemia Reperfusion Injury in Isolated Perfused Rat Heart
dc.typeArticleen_US

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