A New Spectrophotometric Method for Determination of Carvedilol from Tablet

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dc.contributor.authorErek, Figen
dc.contributor.authorAydın, Işıl
dc.date.accessioned2025-03-08T18:25:57Z
dc.date.available2025-03-08T18:25:57Z
dc.date.issued2024
dc.departmentDicle Üniversitesi
dc.descriptionECZ: 19.001
dc.description.abstractIn this study, a new spectrophotometric method was developed for the quantitative analysis of Carvedilol and the method was validated. The method depends on the reaction between the carvedilol and 1,2,5,8-tetrahydroxyanthraquinone in methanol to yield colored charge transfer complex giving maximum absorbance at 560 nm. For optimization of the proposed method, several parameters were investigated such as solvent type, reaction time, and quinalizarin concentration. The stoichiometry of colored charge transfer complex was found to be 2:1(reagent: drug) by Job’s method. Beer’s Law is obeyed in the concentration range of 0.5-60 µg/mL with 0.9986 correlation efficient. Limit of detection (LOD) and limit of quantifiqation (LOQ) were found 0.147 µg/mL, 0.491 µg/mL, respectively. The proposed method can be successfully applied pharmaceutical formulation.
dc.description.abstractIn this study, a new spectrophotometric method was developed for the quantitative analysis of Carvedilol and the method was validated. The method depends on the reaction between the carvedilol and 1,2,5,8-tetrahydroxyanthraquinone in methanol to yield colored charge transfer complex giving maximum absorbance at 560 nm. For optimization of the proposed method, several parameters were investigated such as solvent type, reaction time, and quinalizarin concentration. The stoichiometry of colored charge transfer complex was found to be 2:1(reagent: drug) by Job’s method. Beer’s Law is obeyed in the concentration range of 0.5-60 µg/mL with 0.9986 correlation efficient. Limit of detection (LOD) and limit of quantifiqation (LOQ) were found 0.147 µg/mL, 0.491 µg/mL, respectively. The proposed method can be successfully applied pharmaceutical formulation.
dc.identifier.doi10.34248/bsengineering.1436216
dc.identifier.endpage364
dc.identifier.issn2619-8991
dc.identifier.issue2
dc.identifier.startpage359
dc.identifier.urihttps://doi.org/10.34248/bsengineering.1436216
dc.identifier.urihttps://hdl.handle.net/11468/30481
dc.identifier.volume7
dc.language.isoen
dc.publisherUğur ŞEN
dc.relation.ispartofBlack Sea Journal of Engineering and Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectCharge transfer complex
dc.subjectJob’s method
dc.subjectMolecular absorption spectroscopy
dc.subjectCharge transfer complex
dc.subjectJob’s method
dc.subjectMolecular absorption spectroscopy
dc.titleA New Spectrophotometric Method for Determination of Carvedilol from Tablet
dc.title.alternativeA New Spectrophotometric Method for Determination of Carvedilol from Tablet
dc.typeArticle

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