Delirium With a Single Dosage of Acyclovir in a Continuous Ambulatory Peritoneal Dialysis Patient: Case Report

Basit Öğe Kaydı
dc.contributor.authorKayabasi, Hasan
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorKara, Ismail Hamdi
dc.contributor.authorSit, Dede
dc.contributor.authorYilmaz, M. Emin
dc.date.accessioned2024-04-24T17:44:32Z
dc.date.available2024-04-24T17:44:32Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractValacyclovir is an effective oral agent for the treatment of herpes virus infection, however, the pharmacokinetics of the drug are altered in renal failure. It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity. We studied this drug in a continuous ambulatory peritoneal dialysis (CAPD) and immunocompromised patient. She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection. The elimination half-time (15 h) was similar to that reported for end-stage renal disease patients, while the steady-state volume of distribution (85 l) and the area under the curve concentration (127 mg/l.h) were greater. The mean CAPD dialysance was only 5.27 ml/min with less than 1% of an administered dose being recovered in the 24-hour dialysate. 48 h after interrupting treatment, she recovered normal neurological status and 500 mg of valacyclovir every 2 days was effective and well tolerated.en_US
dc.identifier.endpage37en_US
dc.identifier.issn1300-7718
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://hdl.handle.net/11468/22141
dc.identifier.volume16en_US
dc.identifier.wosWOS:000217149400009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis and Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcyclovir, Toxicity, Delirium, Capden_US
dc.titleDelirium With a Single Dosage of Acyclovir in a Continuous Ambulatory Peritoneal Dialysis Patient: Case Reporten_US
dc.titleDelirium With a Single Dosage of Acyclovir in a Continuous Ambulatory Peritoneal Dialysis Patient: Case Report
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu