Investigation of the Effects of ACE Gene Polymorphism and MTHFR Parameter on Migraine

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dc.contributor.authorEkinci F.U.
dc.contributor.authorAluçlu M.U.
dc.contributor.authorEkinci M.H.
dc.date.accessioned2024-04-24T18:46:35Z
dc.date.available2024-04-24T18:46:35Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: In recent years, some evidence has been presented among control angiotensin converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR) gene mutation, and migraine. The aim of this study is to compare ACE and MTHFR with the migraine control group and to understand the relationship between them. STUDY DESIGN: This study was conducted between September 2012 and January 2013 at the Department of Neurology, Dicle University, Faculty of Medicine. This study consisted of 219 individuals, 119 (mean age 39.4±10.8) of whom were migraine patients and the remaining 100 (mean age 35.5±11.6) of whom made up the control group. In the evaluation of ACE genotype, polymerase chain reaction was determined using real-time PCR technique. RESULTS: The frequency of DD, ID, and II genotypes in the patient group was 33.0%, 61.5%, and 5.2%, respectively, while it was 53.6%, 43.6%, and 2.6% in the control group. It has been statistically shown that the ID genotype in the patient group was highly meaningful as compared to that in the control group. No risk difference has been witnessed both with aura and without aura in the migraine group as compared to the ACE gene DD, ID, and II polymorphism and MTHFR mutations. CONCLUSION: ID genotype was observed frequently in migraine (with and without aura). When the ACE gene was compared with DD, ID, and II polymorphisms and MTHFR mutations, no correlation was detected with or without aura. In our population, no significant increase in the D allele in the ACE gene and MTHFR T mutation was detected. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage336en_US
dc.identifier.issn2578-742X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85129342810
dc.identifier.scopusqualityQ4
dc.identifier.startpage327en_US
dc.identifier.urihttps://hdl.handle.net/11468/25252
dc.identifier.volume43en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAce D/I Ol Mor Hism An İotensin Converting Enzymeen_US
dc.subjectD Allelen_US
dc.subjectGeneen_US
dc.subjectMethylenetetrahydrofolate Reductase Enzymeen_US
dc.subjectMigraineen_US
dc.subjectMthfren_US
dc.subjectMthfr 677c>T Polymorphismen_US
dc.subjectMutationen_US
dc.subjectPolymorphismen_US
dc.titleInvestigation of the Effects of ACE Gene Polymorphism and MTHFR Parameter on Migraineen_US
dc.titleInvestigation of the Effects of ACE Gene Polymorphism and MTHFR Parameter on Migraine
dc.typeArticleen_US

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