LC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent.

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dc.contributor.authorHazman, Omer
dc.contributor.authorAksoy, Lacine
dc.contributor.authorBuyukben, Ahmet
dc.contributor.authorKara, Recep
dc.contributor.authorKargioglu, Mustafa
dc.contributor.authorCigerci, Ibrahim Hakki
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.date.accessioned2024-04-24T17:27:58Z
dc.date.available2024-04-24T17:27:58Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractPlants belonging to the genus Hypericum L. are widely used in traditional folk medicine due to their hypericin and pseudohypericin contents. In this study, we investigated the biological activity, phenolic and elemental content of methanol and acetone extracts of sheepskin grass, Hypericum heterophyllum Vent. a species that that lacks both hypericin and pseudohypericin. The total antioxidant status of the extracts was determined by commercial kits. Antibacterial effect of extracts was investigated on seven bacterial strains. Cytotoxic effects of the extracts on lung cancer cell lines were determined by MTT (3-4,5-dimethyl-thiazolyl-2,5-diphenyltetrazolium bromide) method. Phenolic content was determined by LC-ESI-MS/MS. Elements in the plant were determined by ICP-OES. The total phenolic content and antioxidant status of the species' methanol extract were found to be higher than the acetone extract. Both of the extracts at a concentration of 20% have an antibacterial effect, especially the antibacterial effect of acetone extract. It was determined that acetone extract has an anticarcinogenic impact depending on the dose. Chlorogenic acid, miquelianin and isoquercitrin are the most abundant flavonoids in methanol and acetone extract. The plant contains Ca, K, and Mg elements in high concentrations. The phenolic substances and elements in H. heterophyllum, widely used in our country, have been presented for the first time in the literature. Besides, it can be said that the plant has antioxidant, anticarcinogen, and antimicrobial activities due to the crucial flavonoids and elements it contains.en_US
dc.description.sponsorshipScientific Research Project Fund of Afyon Kocatepe University [18.KARIYER.149]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Afyon Kocatepe University under the Project number 18.KARIYER.149.en_US
dc.identifier.doi10.56042/ijeb.v60i10.55070
dc.identifier.endpage752en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue10en_US
dc.identifier.startpage743en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v60i10.55070
dc.identifier.urihttps://hdl.handle.net/11468/20271
dc.identifier.volume60en_US
dc.identifier.wosWOS:000944885900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicen_US
dc.subjectFolk Medicineen_US
dc.subjectIcp-Oesen_US
dc.subjectPhenolic Contenten_US
dc.subjectSheepskin Grassen_US
dc.subjectTraditional Medicineen_US
dc.titleLC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent.en_US
dc.titleLC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent.
dc.typeArticleen_US

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