Essential oil content, in-vitro and in-silico activities of Hypericum triquetrifolium Turra, H. empetrifolium subsp. empetrifolium Willd., and H. pruinatum Boiss. & Balansa species

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dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYener, Ismail
dc.contributor.authorKocakaya, Safak Ozhan
dc.contributor.authorYolcu, Murat
dc.contributor.authorYigitkan, Serkan
dc.contributor.authorAydin, Firat
dc.contributor.authorTurkmenoglu, Fatma Pinar
dc.date.accessioned2024-04-24T17:20:22Z
dc.date.available2024-04-24T17:20:22Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Aims: The importance of Hypericum species that are used traditionally against many diseases is increasing day by day.Methods: In this study, the essential oil contents of Hypericum triquetrifolium, H. empetrifolium subsp. empetrifolium, and H. pruinatum species were determined with GC-MS/ FID. This is the first study on the antioxidant, anticholinesterase, anti-urease, antityrosinase, antielastase, and anticollagenase activities of these species. Also, in silico and in vitro enzyme in-hibitory activities of the major compounds in the essential oil samples of the species have been evaluated. In addition, the cytotoxic effects of the essential oils were determined by the MTT method.Results: According to GC-MS/ FID results, the major compounds were determined as caryophyllene oxide (16.76%) for H. triquetrifolium, alpha-pinene (21.67%) for H. empetrifolium subsp. empetrifolium, and germacrene D (22.47%) for H. pruinatum. Especially, H. pruinatum sample showed a high cytotoxic effect (IC50: 34.78 +/- 0.22 and 29.06 +/- 0.40 mu g/mL, respectively) on HT -29 and MCF-7 cell lines. It was determined that the same sample showed a promising inhibitory activity on acetyl (18.33 +/- 2.79, 36.48 +/- 2.40, and 56.97 +/- 0.94, respectively) and butyryl (71.63 +/- 2.78, 73.88 +/- 1.16, and 56.97 +/- 0.97, respectively) cholinesterase enzymes.Conclusion: Results of the in-vitro activity studies indicated that H. pruinatum essential oil could be used in the pharmaceuti-cal industry.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Dicle University [Fen. 18.004]; [Eczacimath;limath;k. 20.003.]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Dicle University with the Project numbers: Eczac & imath;l & imath;k. 20.003. and Fen. 18.004.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2023.1024145
dc.identifier.endpage185en_US
dc.identifier.issn2587-2087
dc.identifier.issue2en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2023.1024145
dc.identifier.urihttps://hdl.handle.net/11468/18996
dc.identifier.volume53en_US
dc.identifier.wosWOS:001110261800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Triquetrifoliumen_US
dc.subjectH. Empetrifoliumen_US
dc.subjectH. Pruinatumen_US
dc.subjectEssential Oilen_US
dc.subjectCytotoxicityen_US
dc.subjectAnti-Agingen_US
dc.subjectIn Silicoen_US
dc.titleEssential oil content, in-vitro and in-silico activities of Hypericum triquetrifolium Turra, H. empetrifolium subsp. empetrifolium Willd., and H. pruinatum Boiss. & Balansa speciesen_US
dc.titleEssential oil content, in-vitro and in-silico activities of Hypericum triquetrifolium Turra, H. empetrifolium subsp. empetrifolium Willd., and H. pruinatum Boiss. & Balansa species
dc.typeArticleen_US

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