Effect of graft application and nebivolol treatment on tibial bone defect in rats

Basit Öğe Kaydı
dc.contributor.authorGem M.
dc.contributor.authorŞahin L.
dc.contributor.authorUzel K.
dc.contributor.authorErmiş I.S.
dc.contributor.authorDeveci E.
dc.date.accessioned2024-04-24T18:46:36Z
dc.date.available2024-04-24T18:46:36Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the results of the effect of nebivolol on tibial bone defect and graft application in new bone development in the rat. STUDY DESIGN: Thirty Wistar albino rats were divided into 3 groups. In the Control group, tibia bone defect was created without any treatment. In the Defect+ Graft group, allograft treatment was performed by forming a 6 mm tibial bone defect. In the Defect+Graft+ Nebivolol group, alloplastic bone graft was placed in the calvarial bone defect and then nebivolol (0.34 mg/mL solution/day) treatment was intraperitoneally applied for 28 days. RESULTS: Histopathological examination revealed inflammation in the defect area, congestion in the vessels, degeneration in collagen fibers, and an increase in osteoclast cells. There was an increase in inflammation and blood vessel structure in graft application, and osteoblastic activity matrix formation after reorganization nebivolol application in collagen fibers. Osteonectin expression was positive in the collagen fiber and matrix, starting in the Graft group, in osteoblasts, whereas in the Nebivolol group, osteoblasts increased in osteocytes and new bone formation. CONCLUSION: Nebivolol is thought to have a positive effect on osteoinductive bone growth factors and contribute to the cell-matrix interaction, in addition to the supporting effect of the graft with its antioxidative effect. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage228en_US
dc.identifier.issn2578-742X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85119486946
dc.identifier.scopusqualityQ4
dc.identifier.startpage223en_US
dc.identifier.urihttps://hdl.handle.net/11468/25259
dc.identifier.volume43en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllograften_US
dc.subjectAnimalen_US
dc.subjectBoneen_US
dc.subjectBone Regenerationen_US
dc.subjectDisease Modelsen_US
dc.subjectNebivololen_US
dc.subjectOrthopedic Proceduresen_US
dc.subjectOsteonectinen_US
dc.subjectRatsen_US
dc.subjectTibiaen_US
dc.subjectTibial Defecten_US
dc.titleEffect of graft application and nebivolol treatment on tibial bone defect in ratsen_US
dc.titleEffect of graft application and nebivolol treatment on tibial bone defect in rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu