THE EVALUATION OF PARAOXONASE 1 ACTIVITY IN PATIENTS WITH GESTATIONAL DIABETES

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dc.contributor.authorAtay, Ahmet Engin
dc.contributor.authorSakar, Mehmet Nafi
dc.contributor.authorCulcu, Nurdagul Serife Nurani
dc.contributor.authorSimsek, Hakki
dc.contributor.authorAkbas, Halit
dc.contributor.authorAcar, Murat
dc.contributor.authorIsik, Birgul
dc.date.accessioned2024-04-24T17:49:54Z
dc.date.available2024-04-24T17:49:54Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractMaterial and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.en_US
dc.identifier.endpage657en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://hdl.handle.net/11468/23071
dc.identifier.volume29en_US
dc.identifier.wosWOS:000330151200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParaoxonase Activityen_US
dc.subjectInsulin Resistanceen_US
dc.subjectGestational Diabetesen_US
dc.titleTHE EVALUATION OF PARAOXONASE 1 ACTIVITY IN PATIENTS WITH GESTATIONAL DIABETESen_US
dc.titleTHE EVALUATION OF PARAOXONASE 1 ACTIVITY IN PATIENTS WITH GESTATIONAL DIABETES
dc.typeArticleen_US

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