Effects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion model

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dc.contributor.authorÖzdemir, Hasan Hüseyin
dc.contributor.authorİlhan, Selçuk
dc.contributor.authorDemir, Caner Feyzi
dc.contributor.authorAkgün, Bekir
dc.contributor.authorKapan, Oktay
dc.contributor.authorAtaş, Eser
dc.contributor.authorBerilgen, Muhammed Said
dc.date.accessioned2024-04-24T17:56:10Z
dc.date.available2024-04-24T17:56:10Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractThere are many factors in cerebral ischemia that cause cell death. Glutamate receptor-mediated neurotoxicity is the major mechanism involved in hypoxic-ischemic brain injury (HIBI). Memantine is a low affinity, non-competitive NMDA antagonist blocker, while clopidogrel is an antiplatelet agent used in the treatment of ischemic stroke. The aim of this study is to investigate the effects of clopidogrel and memantine (alone and in combination) on HIBI. Thirty-five Sprague-Dawley rats were exposed to hypoxia for 10 min by ligation of the bilateral common carotid artery. Following this, the rats were divided equally into groups as follows: control, ischemia, memantine (IM), clopidogrel (IC) and memantine + clopidogrel (IMC). Drug therapy was administered for a period of five days, after which all rats were sacrificed and malondialdehyde (MDA), total antioxidant status (TAS), total oxidant (TOS) values, and oxidative stress index (OSI) were determined in brain tissue. MDA and TOS values were significantly higher in the group that underwent ischemia than in the control group. MDA, TOS and OSI values were significantly lower in the groups treated with IM, IC, or IMC than in the group that underwent ischemia. Although it was not significant, TOS and OSI were lower in the groups that underwent combined treatment than in the groups that underwent treatment with IM or IC alone. Our results indicate that memantine and clopidogrel treatment, when used individually, reduce oxidative stress in HIBH more so than when these treatments are combined. This may be due to potential pharmacokinetic mechanisms of the combined therapy.en_US
dc.identifier.citationÖzdemir, H. H., İlhan, S., Demir, C. F., Akgün, B., Kapan, O., Ataş, E. ve diğerleri. (2015). Effects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion model. Neurology Psychiatry and Brain Research, 21(1), 73-77.
dc.identifier.doi10.1016/j.npbr.2014.08.003
dc.identifier.endpage77en_US
dc.identifier.issn0941-9500
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84933278557
dc.identifier.scopusqualityQ3
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.npbr.2014.08.003
dc.identifier.urihttps://hdl.handle.net/11468/23340
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0941950014002012?via%3Dihub
dc.identifier.volume21en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofNeurology Psychiatry and Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebral ischemiaen_US
dc.subjectClopidogrelen_US
dc.subjectMemantineen_US
dc.subjectRaten_US
dc.titleEffects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion modelen_US
dc.titleEffects of memantine and clopidogrel alone and in combination in a cerebral ischemia-reperfusion model
dc.typeArticleen_US

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