Effect of pentoxifylline administration on an experimentalrat model of intraperitoneal adhesion

Basit Öğe Kaydı
dc.authorid0000-0002-7858-454Xen_US
dc.authorid0000-0002-4652-1747en_US
dc.authorid0000-0002-7335-1106en_US
dc.authorid0000-0003-4551-8439en_US
dc.contributor.authorAkgül, Ömer Lütfi
dc.contributor.authorDalbaşı, Erkan
dc.contributor.authorGül, Mesut
dc.contributor.authorAlabalık, Ulaş
dc.date.accessioned2023-09-25T12:33:36Z
dc.date.available2023-09-25T12:33:36Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractAim: Intraabdominal adhesions are the pathological structures that form between the peritoneal surfaces throughout the healing of the peritoneal surface defects with scar formation. Adhesions are a significant problem because they affect the quality of life, lead to morbidity and mortality, and increase health expenses. We have investigated the effectiveness of pentoxifylline (PTX), which is a methyl xanthine derivative, on the development of experimentally generated intraperitoneal adhesions in rats. Materials and Methods: In our study, 30 Wistar Albino rats, each weighing an average of 200-250 grams, were used. In this study, 3 groups of 10 rats were formed. As the adhesion model, cecotomy method was preferred and applied. Groups were classified as; the sham group, control group and PTX group. In the Sham group, merely laparotomy was applied, the control group was intraperitoneal 5 cc isotonic after the cecotomy, and the PTX group was intraperitoneal 100 mg / kg after the cecotomy. Rats were sacrificed on the 15th day. Macroscopic, microscopic adhesion and adhesion tissues were evaluated with regard to hydroxyproline levels. Results: In the comparison of the groups from the macroscopic point of view, there was a noteworthy difference in adhesion between the sham group and the PTX group (p = 0.027) and between the control group and the PTX group (p = 0.001). Conclusion: In this study, it was observed that PTX can reduce intraabdominal adhesion and increase the level of hydroxyproline after surgery.en_US
dc.identifier.citationAkgül, Ö. L., Dalbaşı, E., Gül, M. ve Alabalık, U. (2021). Effect of pentoxifylline administration on an experimentalrat model of intraperitoneal adhesion. Annals of Medical Research, 28(8), 1490-1495.en_US
dc.identifier.doi10.5455/annalsmedres.2020.09.925
dc.identifier.endpage1495en_US
dc.identifier.issn2636-7688
dc.identifier.issue8en_US
dc.identifier.startpage1490en_US
dc.identifier.trdizinid459521
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/459521
dc.identifier.urihttps://hdl.handle.net/11468/12588
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/459521
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAlabalık, Ulaş
dc.language.isoenen_US
dc.publisherİnönü Üniversitesi Tıp Fakültesien_US
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhesionen_US
dc.subjectAbdominal surgeryen_US
dc.subjectPentoxifyllineen_US
dc.titleEffect of pentoxifylline administration on an experimentalrat model of intraperitoneal adhesionen_US
dc.titleEffect of pentoxifylline administration on an experimentalrat model of intraperitoneal adhesion
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Effect of pentoxifylline administration on an experimentalrat model of intraperitoneal adhesion.pdf
Boyut:
748.12 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu