Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults
| dc.contributor.author | Karahan, Oğuz | |
| dc.contributor.author | Etli, Mustafa | |
| dc.date.accessioned | 2024-04-24T19:11:37Z | |
| dc.date.available | 2024-04-24T19:11:37Z | |
| dc.date.issued | 2019 | |
| dc.department | Dicle Üniversitesi | en_US |
| dc.description.abstract | Objectives: This study aims to investigate the predictive role of the signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1)in the presence of endothelial dysfunction.Patients and methods: Between December 2014 and August 2015, 120 healthy young adults (68 males, 52 females; mean age 29.7±4.1 years;range, 20 to 35 years) without a previous history of cardiovascular disease were included. The participants were divided into two groupsaccording to normal (n=73) and abnormal flow-mediated dilatation (FMD) response (n=47). Simultaneously, the standard biochemicalmarkers, blood urea-nitrogen, creatinine, liver enzymes, glucose, lipids and SCUBE-1 levels were determined from the blood samples.Results: Multivariable logistic regression revealed a strong association between SCUBE-1 and FMD (p<0.001). We found that for a cut-offpoint of >136.37 ng/mL, SCUBE-1 had 85.0% sensitivity and 81.2% specificity to identify abnormal FMD.Conclusion: Our study findings indicate that there is a favorable inverse correlation between the SCUBE-1 and FMD. | en_US |
| dc.identifier.doi | 10.9739/tjvs.2019.299 | |
| dc.identifier.endpage | 35 | en_US |
| dc.identifier.issn | 2667-4947 | |
| dc.identifier.issn | 2667-5080 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 31 | en_US |
| dc.identifier.trdizinid | 360500 | |
| dc.identifier.uri | https://doi.org/10.9739/tjvs.2019.299 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/360500 | |
| dc.identifier.uri | https://hdl.handle.net/11468/28111 | |
| dc.identifier.volume | 28 | en_US |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Turkish journal of vascular surgery | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults | en_US |
| dc.title | Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults | |
| dc.type | Article | en_US |
