The effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural study

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dc.contributor.authorAktaş A.
dc.contributor.authorNergiz Y.
dc.contributor.authorAkkuş M.
dc.date.accessioned2024-04-24T18:44:12Z
dc.date.available2024-04-24T18:44:12Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was undertaken to investigate the effect of valproic acid and protective effects of vitamin E and folic acid on rat ovary ultrastructural changes. Twenty-four Wistar rats were used. Animals were divided into four groups. The first group of rats was used as control. The second group was injected valproic acid. The third group was injected valproic acid + folic acid and the fourth group was given valproic acid + vitamin E. At the end of the study, ovarium tissues were taken under anesthesia. Tissues were prepared and examined by transmission electron microscopy. Microscopically, the groups are cited as follows: Control group (in which the ovarium tissue was normal), valproic acid group (which showed increase in lipid content plus mitochondrial crystalysis seen in folliculer and theca interna cells of rat ovarium), valproic acid + folic acid group (in which the theca interna and granulosa cells of rat ovarium had normal appearance) and valproic acid + vitamin E group (where all the organelles of theca interna and granulosa cells of rat ovarium were observed to be normal). Vitamin E and folic acid have protective effects against valproic acid-induced tissue damage in rat ovaries. © 2010 Academic Journals.en_US
dc.identifier.endpage5622en_US
dc.identifier.issn1684-5315
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-80052368857
dc.identifier.scopusqualityN/A
dc.identifier.startpage5616en_US
dc.identifier.urihttps://hdl.handle.net/11468/24606
dc.identifier.volume9en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFolic Aciden_US
dc.subjectOvariumen_US
dc.subjectRaten_US
dc.subjectValproic Aciden_US
dc.subjectVitamin Een_US
dc.titleThe effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural studyen_US
dc.titleThe effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural study
dc.typeArticleen_US

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