Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities

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dc.authorid0000-0002-8325-8116en_US
dc.contributor.authorŞahin, Hasan
dc.contributor.authorSarı, Aynur
dc.contributor.authorÖzsoy, Nurten
dc.contributor.authorÇelik, Berna Özbek
dc.date.accessioned2021-08-17T07:39:18Z
dc.date.available2021-08-17T07:39:18Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.descriptionWOS:000605357000022
dc.description.abstractAbstract Background and Aims: Scorzonera L. genus contains several medicinal and edible plants. Both roots and aerial parts of Scorzonera species are used. S. pygmaea is endemic to Turkey. in a previous study, nine phenolic compounds were reported from the roots of the plant alongside certain biological activities. The current study was designed to investigate the aerial parts of the plant in the same manner and compare the potentials of the two parts. Methods: Chromatographic and spectroscopic methods were used to isolate and identify the phenolics. Total phenolic contents were determined by Folin-Ciocalteu method. FRAP assay, anti-LPO, scavenging DPPH, ABTS and superoxide radicals were employed to evaluate the antioxidant activity. COX inhibition test and micro broth dilution technique were used for anti-inflammatory and antimicrobial activities, respectively. Results: Seven phenolic compounds; thunberginol C (1), protocatechuic acid (2), chlorogenic acid methyl ester (3), cudrabibenzyl A (4), scorzocreticin (5), scorzocreticoside I (6) and II (7) were purified. All the compounds are new for the aerial parts of the plant and 2 is new for the genus. The aerial parts showed a high antioxidant capacity which correlated with its phenolic content. COX inhibitory activity was found to be lower compared to Indomethacin. Weak antimicrobial activity was determined against Staphylococcus aureus and S. epidermidis. Conclusion: Aerial parts possess significant/infrequent phenolics and the ethyl acetate (EtOAc) fraction of the ethanol extract is the most promising fraction for isolating these compounds. Phenolic compositions of aerial parts and roots are very similar. However, aerial parts can be a better rich source of natural antioxidants with protocatechuic acid and higher antioxidant potential.en_US
dc.identifier.citationŞahin, H., Sarı, A., Özsoy, N. ve Çelik, B.Ö. (2020). Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities. Istanbul Journal of Pharmacy, 50(3), 294-299.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2020.0052
dc.identifier.endpage299en_US
dc.identifier.issn2587-2087
dc.identifier.issue3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/13162516DE014B4E89BCC822CCB5FFA1
dc.identifier.urihttps://hdl.handle.net/11468/7342
dc.identifier.volume50en_US
dc.identifier.wosWOS:000605357000022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahin, Hasan
dc.language.isoenen_US
dc.publisherIstanbul Universityen_US
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectScorzonera pygmaeaen_US
dc.subjectPhenolicsen_US
dc.subjectAntioxidanten_US
dc.subjectProtocatechuic aciden_US
dc.titlePhenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activitiesen_US
dc.titlePhenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities
dc.typeArticleen_US

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