The prognostic significance of serum lactate dehydrogenase to albumin ratio in pancreatic ductal adenocarcinoma

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dc.authorid0000-0001-7203-2288en_US
dc.authorid0000-0001-9237-4648en_US
dc.authorid0000-0002-1416-8520en_US
dc.authorid0000-0002-8711-8110en_US
dc.contributor.authorBilge, Hüseyin
dc.contributor.authorBaşol, Ömer
dc.contributor.authorDemir, Baran
dc.contributor.authorOğuz, Abdullah
dc.date.accessioned2023-08-03T05:56:55Z
dc.date.available2023-08-03T05:56:55Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractObjective: This study was performed to investigate the prognostic role of lactate dehydrogenase/albumin ratio (LAR) and pancreatic ductal adenocarcinoma (PDAC) with initial curable resection treatment. Materials and Methods: This retrospective study was conducted with the data of patients with resectable PDAC. The (ROC) analysis showed that the optimal sill value for pretreatment LAR was 91.43 and this threshold value was used in other analyses. Univariate and multivariate analyses were performed to determine the prognostic factors for overall survival (OS). Results: Our study consisted of 70 patients with a mean age of 59.5±13.2 years and 37 (52,9%) women. OS was 50 months in LAR <91.43 (n = 32) patients and 27,7 months in LAR≥91.43 (n=38) patients, respectively. Kaplan–Meier curves showed that LAR≥91.43 was significantly associated with worse OS (p=0.029). Multivariate analyses proved that LAR was an independent predictor in resectable PDAC patients (p=0.017). Conclusion: Our results showed that a high pre-treatment LAR level was a unfavorable prognosticator in PDAC patients undergoing curative resection. LAR has the potential to be a prognostic biomarker in clinical practice.en_US
dc.identifier.citationBilge, H., Başol, Ö., Demir, B. ve Oğuz, A. (2023). The prognostic significance of serum lactate dehydrogenase to albumin ratio in pancreatic ductal adenocarcinoma. Acta Medica, 54(2), 109-115.en_US
dc.identifier.doi10.32552/2023.ActaMedica.819
dc.identifier.endpage115en_US
dc.identifier.issn2147-9488
dc.identifier.issue2en_US
dc.identifier.startpage109en_US
dc.identifier.trdizinid1188613
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188613
dc.identifier.urihttps://hdl.handle.net/11468/12408
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1188613
dc.identifier.volume54en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDemir, Baran
dc.institutionauthorOğuz, Abdullah
dc.language.isoenen_US
dc.publisherHacettepe University Faculty of Medicineen_US
dc.relation.ispartofActa Medica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPancreas ductal adenocarcinomaen_US
dc.subjectLactic dehydrogenaseen_US
dc.subjectAlbuminen_US
dc.subjectLARen_US
dc.subjectSurvivalen_US
dc.titleThe prognostic significance of serum lactate dehydrogenase to albumin ratio in pancreatic ductal adenocarcinomaen_US
dc.titleThe prognostic significance of serum lactate dehydrogenase to albumin ratio in pancreatic ductal adenocarcinoma
dc.typeArticleen_US

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