Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort

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dc.contributor.authorPihtili, Aylin
dc.contributor.authorKiyan, Esen
dc.contributor.authorBalcan, Baran
dc.contributor.authorArbatli, Semih
dc.contributor.authorCilli, Aykut
dc.contributor.authorAltintas, Nejat
dc.contributor.authorUgurlu, Aylin Özsancak
dc.date.accessioned2025-02-22T14:10:55Z
dc.date.available2025-02-22T14:10:55Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis. OSA was defined as an apnea-hypopnea index (AHI) ≥5 events/hour and was classified as mild, moderate, and severe according to AHI cut-offs 5, 15, and 30 events/hour, respectively. Results: In all, 7130 patients (2259 women) were included. OSA was observed in 6323 (88.7 %), of whom 70.2 % were male and 29.8 % were female. In the OSA group, women were older (56.7 ± 11.9 vs. 49.5 ± 11.3 years; p < 0.001) and more obese (body mass index 34.3 ± 7.2 vs. 31.4 ± 5.6 kg/m2; p < 0.001) and had lower AHI (29.8 ± 24.1 vs. 36.8 ± 26.2 events/h; p < 0.001) than men. Loud snoring and witnessed apnea were more common in men than in women whereas women were more frequently presented with insomnia, headache, and mood changes. Women had significantly less total sleep time, less sleep efficiency, and longer sleep latency compared with men (p < 0.001 for each). Additionally, comorbid diseases such as diabetes mellitus, hypertension, asthma, psychiatric disorders, hypothyroidism as well as drug use were more common in women than in men independent of age and obesity (p < 0.05 for each). Conclusions: Our results suggest significant sex differences in clinical and polysomnographic features in this nationwide Turkish adult population. Women with OSA have more symptom burden and comorbidities despite having a less severe AHI. © 2024 The Authorsen_US
dc.description.sponsorshipBundesministerium des Innern, für Bau und Heimat, BMI; ResMed Foundation; Data Monitoring Board; Turkish Thoracic Societyen_US
dc.identifier.doi10.1016/j.sleep.2024.12.018
dc.identifier.endpage234en_US
dc.identifier.issn1389-9457
dc.identifier.scopus2-s2.0-85212914713en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1016/j.sleep.2024.12.018
dc.identifier.urihttps://hdl.handle.net/11468/29875
dc.identifier.volume126en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSleep Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250222
dc.subjectObstructive sleep apneaen_US
dc.subjectPolysomnographyen_US
dc.subjectSexen_US
dc.subjectSymptomsen_US
dc.titleSex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohorten_US
dc.typeArticleen_US

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