Protective Role of Lycopene on Aflatoxin B1 Induced Changes Sperm Characteristics and Testicular Damages in Rats

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dc.contributor.authorTas, Muzaffer
dc.contributor.authorSaruhan, Berna Gueney
dc.contributor.authorKurt, Dogan
dc.contributor.authorYokus, Beran
dc.contributor.authorDenli, Muzaffer
dc.date.accessioned2024-04-24T17:44:51Z
dc.date.available2024-04-24T17:44:51Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate if lycopene could diminish the adverse effects of aflatoxin B-1 (AFB(1)) on sperm characteristics, the testes, epididymis and oxidative stress in rats. A total of 28 adult male Wistar-Albino rats (8 weeks old weighing 180-220 g) were divided into four groups; Controls, lycopene treated rats (10 mg/kg BW, daily by gavage), AFB(1) treated rats (2.5 mg/kg BW, single dose intra peritonal) and lycopene (10 mg/kg BW, daily by gavage) + AFB(1) (2.5 mg/kg BW, single dose intra peritonal) treated rats. Traits of reproductive organs (testes and sperm characteristics, testicular histological findings and the testicular tissue oxidative status) were determined after 15 days of treatment. The sperm motility was significantly decreased while the rate of total abnormal sperms was significantly increased in rats treated with AFB(1) alone compared to their levels in controls (P<0.001). The level of testes malondialdehyde (MDA) in rats treated with AFB(1) was significantly higher than its level in controls (P<0.001). Treatment with AFB(1) significantly decreased testes diameter and seminifer epithelium thickness (P<0.0001) when compared with the others. Similarly, the thickness of the germinative cell layer at seminifer tubul (ST) in rats treated with AFB(1) was significantly smaller than controls. Treatment with lycopene significantly increased sperm motility (P<0.001) and alleviated the many negative effects of AFB(1) on sperm characteristic and testicular damage in rats. In conclusion our results showed that consumption of 10 mg of lycopene/BW given by gavage protected the rats to the toxicity of AFB(1) when it is administrated as a single dose intraperitoneally.en_US
dc.identifier.endpage604en_US
dc.identifier.issn1300-6045
dc.identifier.issue4en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://hdl.handle.net/11468/22312
dc.identifier.volume16en_US
dc.identifier.wosWOS:000278958100011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlfatoxin B-1en_US
dc.subjectLycopeneen_US
dc.subjectSperm Qualityen_US
dc.subjectTestesen_US
dc.subjectEpididymisen_US
dc.subjectRaten_US
dc.titleProtective Role of Lycopene on Aflatoxin B1 Induced Changes Sperm Characteristics and Testicular Damages in Ratsen_US
dc.titleProtective Role of Lycopene on Aflatoxin B1 Induced Changes Sperm Characteristics and Testicular Damages in Rats
dc.typeArticleen_US

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