Retinoic acid syndrome after the first dose of all-trans retinoic acid

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dc.contributor.authorAltintaş A.
dc.contributor.authorPaşa S.
dc.contributor.authorAğgil C.
dc.contributor.authorTural B.
dc.contributor.authorAyyildiz O.
dc.date.accessioned2024-04-24T18:43:39Z
dc.date.available2024-04-24T18:43:39Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractAll-trans retinoic acid (ATRA) was firstly used as a differentiating agent in 1987 in Shanghai for the treatment of acute promyelocytic leukemia (APL). Retinoic Acid Syndrome (RAS) became an important complication of therapy after the administration of ATRA. The frequency of syndrome is 27% and the precise cause is not entirely known. The mortality rate of patients with APL due to this complication is 1%. Symptoms of RAS resembles to sepsis, pneumonia, iatrogenic volume overload and blood transfusion reactions frequently seen in the course of leukemia and may cause confusion in the diagnosis of RAS. Dexamethasone must be administered urgently in the suspicion of RAS since it has a fatal outcome. Herein, we reported an APL patient with white blood cell count of lower than 1000/ml at presentation and complicated with retinoic acid syndrome subsequent to the first dose of all-trans retinoic acid.en_US
dc.identifier.endpage148en_US
dc.identifier.issn1306-133X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33749985992en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://hdl.handle.net/11468/24250
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofUHOD - Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Promyelocytic Leukemiaen_US
dc.subjectAll-Trans Retinoic Aciden_US
dc.subjectRetinoic Acid Syndromeen_US
dc.titleRetinoic acid syndrome after the first dose of all-trans retinoic aciden_US
dc.title.alternativeİlk doz all-trans retinoik asit sonrasi gelişen retinoik asit sendromu bir olgu sunumuen_US
dc.typeArticleen_US

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