The relationship between 68Ga-PSMA uptake and Gleason Score and PSA levels in patients with prostate cancer

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dc.contributor.authorAltuntuzcu, Şadiye
dc.contributor.authorTaşdemir, Bekir
dc.contributor.authorKaplan, İhsan
dc.contributor.authorUyar, Ali
dc.contributor.authorGüzel, Fatih
dc.contributor.authorGüzel, Yunus
dc.contributor.authorDağgülli, Mansur
dc.date.accessioned2025-03-08T18:25:42Z
dc.date.available2025-03-08T18:25:42Z
dc.date.issued2021
dc.departmentDicle Üniversitesi
dc.description359-2021
dc.description.abstractAim: PSMA expression has been observed in increased levels in patients with high Gleason scores. Current information on Ga-68 PSMA PET/CT shows that primary staging with PET/CT is important in patients with high-risk PC. Ga-68 PSMA PET/CT may also have a place in patients with intermediate risk PC, but only a few data are available at present. In this study, we aimed to elucidate the relationship between PSMA expression value in the prostate gland, total PSA levels and GS in patients diagnosed with prostate cancer. Material and Method: A total of 98 patients who were pathologically diagnosed with prostate cancer that did not receive any treatment and underwent Ga-68 PSMA PET/CT imaging for staging were included in the study. Findings detected in Ga-68 PSMA PET/CT imaging were categorized as prostate, lymph node, bone, and visceral organ. The focal increased PSMA expression values ??observed in the prostate gland were recorded as SUVmax. The patients were divided into two separate groups according to their GS score (GS>7 and GS?7). Correlations between prostate PSMA SUVmax, GS score and total PSA scores were investigated. Results: PSMA SUVmax levels of the group with a Gleason score of >7 were found to be significantly higher than the group with a Gleason score of ?7 (p=0.03). The rates of lymph node metastasis, bone metastasis and visceral organ metastases were found to be significantly higher in the group with a Gleason score >7 compared to the group with a Gleason score ?7. A positive correlation was observed between PSMA SUVmax and Total PSA (r=0.260, p=0.01). A positive correlation was observed between PSMA SUVmax and Gleason score (r=0.260, p=0.01). A positive correlation was observed between total PSA and Gleason score (r=0.320, p=0.001). Conclusion: In conclusion, PSMA SUVmax and Total PSA levels were higher in the group with high Gleason score. There is a positive correlation between PSMA SUVmax and total PSA. Clinicians should be careful in this regard, as the possibility of metastasis will be high in groups with high Gleason scores.
dc.identifier.doi10.38053/acmj.990403
dc.identifier.endpage332
dc.identifier.issn2718-0115
dc.identifier.issue4
dc.identifier.startpage327
dc.identifier.urihttps://doi.org/10.38053/acmj.990403
dc.identifier.urihttps://hdl.handle.net/11468/30350
dc.identifier.volume3
dc.language.isoen
dc.publisherMediHealth Academy Yayıncılık
dc.relation.ispartofAnatolian Current Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectProstate specific membrane antigen
dc.subjectprostate cancer
dc.subjectGa-68 PSMA PET/CT
dc.subjectProstate specific membrane antigen
dc.subjectprostate cancer
dc.subjectGa-68 PSMA PET/CT
dc.titleThe relationship between 68Ga-PSMA uptake and Gleason Score and PSA levels in patients with prostate cancer
dc.typeArticle

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