Retrospective Analysis of Demographic and Laboratory Data of Patients with Hepatocellular Carcinoma: Single Center Experience
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: Hepatocellular carcinoma (HCC) is an aggressive tumor that frequently occurs in thesetting of chronic liver disease and cirrhosis. In this study, we aim to evaluate the etiologic factors associatedwith Hepatocellular carcinoma and their role on the clinical outcome and prognosis of the disease.METHODS: A total of 377 patients were included in the study. Patient files were retrospectively analyzed.HCC was diagnosed based on radiologic, histologic, clinical and laboratory findings. Patients were groupedaccording to etiology.RESULTS: The mean age of the patients was 58.70±2.50 years and 82.2% of them were male. The vastmajority of the patients were living in the city center, and 67.6% of them had primary education or lowereducation level. It was seen that HCC developed in cirrhosis base in 87% of the patients. When we looked at theetiologic factors, 57.8% of the patients were found to develop due to HBV, 15.6% to HDV, 8.2% to HCV and18.3% to non-viral causes. The mean duration of infection was 9.38±9.08 years and 23.6% were taking antiviraltreatment in patients with HSC due to viral etiology.DISCUSSION AND CONCLUSION: Viral hepatitis is the most important risk factor for the development ofHCC, and HCC often develops on the basis of cirrhosis. Therefore, the follow up and treatment of patients withchronic viral hepatitis and cirrhosis is of great importance. Patients with HCC in our region with low rates ofanti-viral treatment and high Child-Pugh score suggest that this is still a serious health problem that is stillimportant. Increased awareness of viral hepatitis is evident when the incidence of HCC is reduced by vaccinationprograms, and patients with cirrhosis will be diagnosed with HCC at an earlier stage with regular follow-upprograms and will have a long-term survival benefit with more effective treatment options.
Açıklama
Anahtar Kelimeler
Kaynak
ACTA ONCOLOGICA TURCICA
WoS Q Değeri
Scopus Q Değeri
Cilt
52
Sayı
1
