The evaluation of paraoxonase 1 activity in patients with gestational diabetes

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dc.contributor.authorAtay A.E.
dc.contributor.authorSakar M.N.
dc.contributor.authorCulcu N.S.N.
dc.contributor.authorSimsek H.
dc.contributor.authorAkbas H.
dc.contributor.authorAcar M.
dc.contributor.authorIsik B.
dc.date.accessioned2024-04-24T18:45:46Z
dc.date.available2024-04-24T18:45:46Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractMaterial and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.en_US
dc.identifier.endpage657en_US
dc.identifier.issn0393-6384
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84896700396
dc.identifier.scopusqualityN/A
dc.identifier.startpage653en_US
dc.identifier.urihttps://hdl.handle.net/11468/24869
dc.identifier.volume29en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherActa Medica Mediterraneaen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational Diabetesen_US
dc.subjectInsulin Resistanceen_US
dc.subjectParaoxonase Activityen_US
dc.titleThe evaluation of paraoxonase 1 activity in patients with gestational diabetesen_US
dc.titleThe evaluation of paraoxonase 1 activity in patients with gestational diabetes
dc.typeArticleen_US

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