Protective role of lycopene on aflatoxin B1 induced changes sperm characteristics and testicular damages in rats

Basit Öğe Kaydı
dc.contributor.authorTaş M.
dc.contributor.authorGüney Saruhan B.
dc.contributor.authorKurt D.
dc.contributor.authorYokuş B.
dc.contributor.authorDenli M.
dc.date.accessioned2024-04-24T17:58:58Z
dc.date.available2024-04-24T17:58:58Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate if lycopene could diminish the adverse effects of aflatoxin B1 (AFB1) on sperm characteristics, the testes, epididymis and oxidative stress in rats. A total of 28 adult male Wistar-Albino rats (8 weeks old weighing 180-220 g) were divided into four groups; Controls, lycopene treated rats (10 mg/kg BW, daily by gavage), AFB1 treated rats (2.5 mg/kg BW, single dose intra peritonal) and lycopene (10 mg/kg BW, daily by gavage) + AFB1 (2.5 mg/kg BW, single dose intra peritonal) treated rats. Traits of reproductive organs (testes and sperm characteristics, testicular histological findings and the testicular tissue oxidative status) were determined after 15 days of treatment. The sperm motility was significantly decreased while the rate of total abnormal sperms was significantly increased in rats treated with AFB1 alone compared to their levels in controls (P<0.001). The level of testes malondialdehyde (MDA) in rats treated with AFB1 was significantly higher than its level in controls (P<0.001). Treatment with AFB1 significantly decreased testes diameter and seminifer epithelium thickness (P<0.0001) when compared with the others. Similarly, the thickness of the germinative cell layer at seminifer tubul (ST) in rats treated with AFB1 was significantly smaller than controls. Treatment with lycopene significantly increased sperm motility (P<0.001) and alleviated the many negative effects of AFB1 on sperm characteristic and testicular damage in rats. In conclusion our results showed that consumption of 10 mg of lycopene/ BW given by gavage protected the rats to the toxicity of AFB1 when it is administrated as a single dose intraperitoneally.en_US
dc.identifier.endpage604en_US
dc.identifier.issn1300-6045
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-77954272434en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://hdl.handle.net/11468/24173
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlfatoxin B1en_US
dc.subjectEpididymisen_US
dc.subjectLycopeneen_US
dc.subjectRaten_US
dc.subjectSperm Qualityen_US
dc.subjectTestesen_US
dc.titleProtective role of lycopene on aflatoxin B1 induced changes sperm characteristics and testicular damages in ratsen_US
dc.title.alternativeRatlarda aflatoksin B1'in spermatozoa özellikleri ve testislerde yaratti?i hasar üzerine likopenin koruyucu etkisien_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu