Protective effects of L-Arginine and pentoxifylline on mucosal barrier in ischemia-reperfusion induced gastric injury in rats

Basit Öğe Kaydı
dc.contributor.authorÖnen A.
dc.contributor.authorKanay Z.
dc.contributor.authorKurt D.
dc.date.accessioned2024-04-24T17:58:39Z
dc.date.available2024-04-24T17:58:39Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To determine the effects L-Arginine (L-Arg) and pentoxifylline (Ptx) on mucosal barrier in ischemia-reperfusion (IR) induced gastric injury in rats. Method: Twenty-eight males, adult Wistar Albino rats (200-250 g) were used in the study. The rats were anesthetized by ketamine hydrokloride. Laparotomy only was applied in control group (n=7). In other three groups, coeliac artery was occluded for a period of 30 minutes followed by a reperfusion period of 60 minutes. No drug was given in IR group (n=7). In Ptx+IR group (n=7), 50 mg/kg Ptx was administered intraperitoneally before reperfusion. In L-Arg+IR group (n=7), 3 mg/kg/minute L-Arginine was increased immediately before refursion. The amounts of mucus and phospholipid were determined by Corne and Baur's methods. Ulcer index was measured via counting macroscopical petechial hemorrhage. Results: Mucus and phospholipid levels in gastric mucosa were significantly lower in IR group compared to control group (p<0.01). The amount of phospholipid was significantly higher in both Ptx+IR and L-Arg+IR groups when compared to those of IR group (p<0.01), while there were no significant differences between Ptx+IR and L-Arg+IR and IR group in terms of mucus amount (p>0.05). Phospholipid level was significantly higher in L-Arg+IR group when compared to Ptx+IR group (p<0.01), while there was no significant difference between these two groups from the point of mucus amount (p>0.05). Ulcer index was significantly higher in IR group than Ptx+IR and L-Arg+IR groups (p<0.05, p<0.01). Conclusion: Gastric IR breaks mucosal barrier through significantly decreased mucus and phospholipid levels and results in gastric mucosal damage via increased ulcer index. Ptx and L-Arg diminish barrier breakage and mucosal damage induced by IR. L-Arg seems to protect the gastric mucosal barrier better than Ptx does.en_US
dc.identifier.endpage78en_US
dc.identifier.issn1016-5142
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0142198410en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/11468/24036
dc.identifier.volume17en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofPediatrik Cerrahi Dergisien_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectL-Arginineen_US
dc.subjectMucusen_US
dc.subjectPentoxifyllineen_US
dc.subjectPhospholipiden_US
dc.titleProtective effects of L-Arginine and pentoxifylline on mucosal barrier in ischemia-reperfusion induced gastric injury in ratsen_US
dc.title.alternativeL-Arginin ve pentoksifilinin mide iskemi-reperfüizyonu uygulanan siçanlarda mukoza engeli üzerindeki koruyucu etkilerien_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu