Nitrendipine and stress-induced ulcers: Preliminary tudy

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dc.contributor.authorInalöz S.
dc.contributor.authorOzaydin M.
dc.contributor.authorSari I.
dc.contributor.authorCicek R.
dc.contributor.authorGuney B.
dc.contributor.authorYenice N.
dc.date.accessioned2024-04-24T18:44:03Z
dc.date.available2024-04-24T18:44:03Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractNitrendipine is a derivative of the dihydropyridine of calcium channel blockers and released for angina and hypertension. The therapeutic effect of nitrendipine was observed histologically against stress-induced gastric and duodenal ulcers in rats. Twenty-four male Wistar-albino rats were separated into three groups (n = 8), a control (non-stress) and two stress groups. The stressed group rats were exposed to starvation and cold-restraint in this study. The first stress group was given only a placebo whereas the second stress group was treated with nitrendipine. After treatment with nitrendipine, the total rea of the affected lesional mucosa was considerably reduced in both duodenal and gastric mucosa. Macroscopically, the surface area of the affected lesional mucosa was measured as 1/5 of the total duodenal mucosa. Moreover, the surface area of the affected lesional mucosa was measured as 1/8 of the total surface area in the stomach. In microscopic examination, tissue regeneration was conspicuous particularly in the gastric epithelium. A few hyperchromatic epithelial cells were noticed in some fields of the duodenal mucosa. Furthermore, tissue regeneration was not conspicuous as in the gastric mucosa. So we think that nitrendipine can be used in both gastric and duodenal stress ulcer treatment. However, in the healing process, therapeutic effect of nitrendipine was superior in stomach with conspicuous tissue regeneration.en_US
dc.identifier.endpage146en_US
dc.identifier.issn0291-1981
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0030756895en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://hdl.handle.net/11468/24537
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofJournal de Pharmacie Cliniqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistopathologyen_US
dc.subjectNitrendipineen_US
dc.subjectStress-İnduced Ulceren_US
dc.titleNitrendipine and stress-induced ulcers: Preliminary tudyen_US
dc.typeArticleen_US

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