The dexamethasone suppression test in depressive and non-depressive patients with fibromyalgia

dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorSır, Aytekin
dc.contributor.authorSaraç, Jale
dc.contributor.authorNas, Kemal
dc.contributor.authorÖzkan, Mustafa
dc.contributor.authorErdoğan, Ferda
dc.contributor.authorAtaoğlu, Ahmet
dc.date.accessioned2024-04-24T18:56:38Z
dc.date.available2024-04-24T18:56:38Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn most healthy individuals, dexamethasone suppresses adrenal cortisol production. However, in patients with depression, non-suppression frequently occurs. It is considered to be a hyperactivity of the limbichypothalamic pituitary-adrenal (LHPA) axis. To investigate a possible link between fibromyalgia and depression on the basis of response to dexamethasone suppression test (DST), we administered the DST to 20 fibromyalgia patients with depression, 26 nondepressive patients with fibromyalgia and 20 controls. In the fibromyalgia patients with depression. at the mean 16.00 hr, post dexamethasone plasma cortisol level was found significant (LSD: 0.655: p<0.05). (LSD: 0.657: p<0.05), compared to non-depressive patients with fibromyalgia and the controls. There was no significant difference between post dexamethasone plasma cortisol levels in the non-depressive patients with fibromyalgia and control group (LSD: 0.655: p>0.05). In the fibromyalgia patients with depression, seven subjects had a non-suppressed response to the DST, which was significant relative to other two groups (P<0.05). In the non-depressive fibromyalgia group, only one subject had a non-suppressed response to the DST. In the control group, all subjects showed a suppressed response to the DST, There were no significant differences in the supression rates between the non-depressive patients with fibromyalgia and control group (P>0.05). Our findings show that fibromyalgia may not be related to hyperactivity of the LHPA axis.en_US
dc.identifier.endpage450en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.startpage447en_US
dc.identifier.trdizinid43250
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/43250
dc.identifier.urihttps://hdl.handle.net/11468/25331
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe dexamethasone suppression test in depressive and non-depressive patients with fibromyalgiaen_US
dc.titleThe dexamethasone suppression test in depressive and non-depressive patients with fibromyalgia
dc.typeOtheren_US

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