Efficacy of taxifolin in the prevention of renal injury due to liver ischemia and reperfusion

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dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorDurgun, Hasan Mansur
dc.contributor.authorAşır, Fırat
dc.contributor.authorVarlı, Metin
dc.contributor.authorGündüz, Ercan
dc.date.accessioned2024-04-24T19:13:28Z
dc.date.available2024-04-24T19:13:28Z
dc.date.issued2023
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Bilimler Bölümü, Genel Cerrahi Anabilim Dalıen_US
dc.description.abstractAim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion. Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group. Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-? expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05). Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects.en_US
dc.identifier.citationÜlger, B.V., Aşır, F., Varlı, M., Gündüz, E. ve Durgun, H.M. (2023). Efficacy of taxifolin in the prevention of renal injury due to liver ischemia and reperfusion. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(3), 503-507.
dc.identifier.doi10.36516/jocass.1371823
dc.identifier.endpage507en_US
dc.identifier.issn2667-498X
dc.identifier.issue3en_US
dc.identifier.startpage503en_US
dc.identifier.trdizinid1222213
dc.identifier.urihttps://doi.org/10.36516/jocass.1371823
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1222213
dc.identifier.urihttps://hdl.handle.net/11468/28622
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÜlger, Burak Veli
dc.institutionauthorDurgun, Hasan Mansur
dc.institutionauthorAşır, Fırat
dc.institutionauthorGündüz, Ercan
dc.language.isoenen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver ischemia
dc.subjectReperfusion
dc.subjectTaxifolin
dc.subjectHistopathology
dc.subjectImmunohistochemistry
dc.subjectOxidative stress
dc.titleEfficacy of taxifolin in the prevention of renal injury due to liver ischemia and reperfusionen_US
dc.titleEfficacy of taxifolin in the prevention of renal injury due to liver ischemia and reperfusion
dc.typeArticleen_US

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