Treatment of advanced chronic lymphocytic leukemia by fludarabine

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dc.contributor.authorAyyildiz, O
dc.contributor.authorTiftik, N
dc.contributor.authorBolaman, Z
dc.contributor.authorMüftüoglu, E
dc.date.accessioned2024-04-24T17:40:12Z
dc.date.available2024-04-24T17:40:12Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description12th Mediterranean Congress of Chemotherapy -- NOV 11-14, 2000 -- MARRAKECH, MOROCCOen_US
dc.description.abstractTen patients with B-cell chronic lymphocytic leukemia (CLL), aged 55-72 years, 9 male and 1 female, were treated with fludarabine. Fludarabine is the most active agent for treatment of CLL. All patients were previously treated with alkylating agent-based regimen. Fludarabine was administered for 5 consecutive days 25 mg/m(2)/d and repeated 4-weekly. The response rate was 40% with 1 complete response and 3 partial responses. However, four patients achieved stable disease and 2 progressed. The median survival for responders was 18 months and for non-responders 8 months. Our patients tolerated the fludarabine treatment extremely well. Myelosupression was seen in eight patients. In a total of 37 treatment courses 5 febrile episodes were registered in 4 patients and successfully treated with empirical antibiotic regimen. In conclusion, fludarabine is effective in CLL patients refractory to first-line chemotherapy.en_US
dc.identifier.endpage121en_US
dc.identifier.isbn88-323-0211-X
dc.identifier.startpage117en_US
dc.identifier.urihttps://hdl.handle.net/11468/21678
dc.identifier.wosWOS:000172402200018
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherMedimond S R Len_US
dc.relation.ispartof12th Mediterranean Congress of Chemotherapy
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleTreatment of advanced chronic lymphocytic leukemia by fludarabineen_US
dc.titleTreatment of advanced chronic lymphocytic leukemia by fludarabine
dc.typeConference Objecten_US

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