The effects of clomiphene citrate administration in ovariectomised rats: An ultrastructural study

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dc.contributor.authorSaruhan, Berna Güney
dc.contributor.authorKetani, Muzaffer Aydın
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorIlgaz, Celal
dc.contributor.authorAkkuş, Murat
dc.contributor.authorKetani, Şennur
dc.date.accessioned2024-04-24T17:58:17Z
dc.date.available2024-04-24T17:58:17Z
dc.date.issued2008
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Veterinerlik Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractIn this study, we aimed to investigate Clomiphene Citrate (CC) on vagen of adult Ovariectomised rats. Transmission electron microscopy and light microscopy have been used to study changes to the vaginal epithelium induced by C administered to Ovariectomised rats. The study was performed in Department of Medical Science Application and Research Centre of Dicle University, DUSAM-Turkey in 2001. Ten female, Wistar Albino rats were used and were divided into three groups. At the beginning and end of the administrations, body weight of animals was determined. Animals were sacrificed 35 days after ovariectomised and vaginal tissue was examined by transmission electron microscopy and light microscopy. We found that, the body weight was higher in the ovariectomized rats than the control rats. Further, body weight increased after clomiphene citrate therapy. It was found that clomiphene citrate treatment produced ultra structural surface features some of which were similar to those seen with hormone treatments and others unique to clomiphene alone. In conclusion, antiestrogen clomiphene citrate administration affects vagina epithelium and lead to increasing body weight.en_US
dc.identifier.citationSaruhan, B. G., Ketani, M. A., Nergiz, Y., Ilgaz, C., Akkuş, M. ve Ketani, Ş. (2008). The effects of clomiphene citrate administration in ovariectomised rats: An ultrastructural study. Journal of Biological Sciences, 8(1), 60-66.
dc.identifier.doi10.3923/jbs.2008.60.66
dc.identifier.endpage66en_US
dc.identifier.issn1727-3048
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-42449132190
dc.identifier.scopusqualityN/A
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.3923/jbs.2008.60.66
dc.identifier.urihttps://hdl.handle.net/11468/23795
dc.identifier.volume8en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAsian Network for Scientific Informationen_US
dc.relation.ispartofJournal of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClomiphene citrateen_US
dc.subjectRaten_US
dc.subjectUltrastructural changesen_US
dc.subjectVaginaen_US
dc.titleThe effects of clomiphene citrate administration in ovariectomised rats: An ultrastructural studyen_US
dc.titleThe effects of clomiphene citrate administration in ovariectomised rats: An ultrastructural study
dc.typeArticleen_US

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