The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats

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dc.contributor.authorAksoy, Hülya
dc.contributor.authorAkçay, Fatih
dc.contributor.authorToker, Aysun
dc.contributor.authorSüleyman, Halis
dc.contributor.authorErdem, Havva
dc.contributor.authorÖzgen, Ufuk
dc.date.accessioned2024-04-24T19:05:07Z
dc.date.available2024-04-24T19:05:07Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: We investigated the effects of acetyl shikonin isolated from Onosma armeniacum on ethanol-induced gastric injury (ulcer) and on oxidant antioxidant parameters in the gastric tissue of rats. Materials and methods: Eighteen albino Wistar male rats were divided into 3 different experimental groups. Group 1 (n = 6) was the control group, group 2 (n = 6) was the ethanol group, and group 3 (n = 6) was the acetyl shikonin + ethanol group. The animals in group 3 were given ethanol (1 mL, 50% v/v) 30 min after acetyl shikonin (40 mg/kg) administration by orogastric tube. Results: The lowest mean nitric oxide level; the lowest superoxide dismutase, glutathione peroxidase, and glutathione S-transferase activities; and the highest malondialdehyde level and myeloperoxidase activity were obtained in group 2. It was observed that acetyl shikonin increased the activities of antioxidant enzymes and the level of nitric oxide and decreased the level of malondialdehyde and the activity of myeloperoxidase in group 3. In histopathological evaluation, minimal lymphocyte infiltration and edema were seen but no ulcerations were observed in group 3. Conclusion: The data revealed that the antiulcer effect of acetyl shikonin might be due to an increase in antioxidant enzyme activity and nitric oxide levels, and a decrease in malondialdehyde levels and myeloperoxidase activityen_US
dc.identifier.endpage320en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.startpage315en_US
dc.identifier.trdizinid211655
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/211655
dc.identifier.urihttps://hdl.handle.net/11468/27068
dc.identifier.volume43en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of ratsen_US
dc.titleThe effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats
dc.typeArticleen_US

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