SOME NOVEL SCHIFF BASE DERIVATIVES AS PROMISING CHOLINESTERASE INHIBITORS WITH ANTIOXIDANT ACTIVITY AGAINST ALZHEIMER’S DISEASE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION

Basit Öğe Kaydı
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorÇınar, Ercan
dc.contributor.authorTopal, Giray
dc.contributor.authorÇakmak, Reşit
dc.date.accessioned2024-04-24T19:13:16Z
dc.date.available2024-04-24T19:13:16Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, five novel Schiff base derivatives (6-10) except for 9 were synthesized for the first time, characterized, and tested for their inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Also, the Antioxidant activities of these molecules were examined by DPPH and ABTS assays. Their molecular structures were characterized by three spectroscopic techniques. In AChE assay, compound 6 (95.87±1.59 % inhibition) inhibited this enzyme better than galanthamine (76.98±0.42 % inhibition). In BChE assay, compound 10 with an 87.92±1.08% inhibition value in the series indicated the highest activity compared to galanthamine (76.30±0.28 % inhibition). In ABTS radical scavenging assay, compounds 7, 8, and 9 except for 6 and 10 indicated higher antioxidant activities compared to butylated hydroxytoluene (BHT). It is believed that these results may contribute to the design and synthesis of novel antioxidant agents, AChE, and BChE inhibitors.en_US
dc.identifier.doi10.51477/mejs.1204413
dc.identifier.endpage146en_US
dc.identifier.issn2618-6136
dc.identifier.issue2en_US
dc.identifier.startpage138en_US
dc.identifier.trdizinid1147727
dc.identifier.urihttps://doi.org/10.51477/mejs.1204413
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1147727
dc.identifier.urihttps://hdl.handle.net/11468/28503
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofMiddle East Journal of Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSOME NOVEL SCHIFF BASE DERIVATIVES AS PROMISING CHOLINESTERASE INHIBITORS WITH ANTIOXIDANT ACTIVITY AGAINST ALZHEIMER’S DISEASE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATIONen_US
dc.titleSOME NOVEL SCHIFF BASE DERIVATIVES AS PROMISING CHOLINESTERASE INHIBITORS WITH ANTIOXIDANT ACTIVITY AGAINST ALZHEIMER’S DISEASE: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu