The VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo Hemorrhagic Fever patients.

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dc.contributor.authorTurkdogan, Kenan Ahmet
dc.contributor.authorKarabacak, Mustafa
dc.contributor.authorAkpinar, Orhan
dc.contributor.authorKarahan, Oguz
dc.contributor.authorGuven, Fatma Mutlu Kukul
dc.contributor.authorEngin, Aynur
dc.contributor.authorTurkdogan, Figen Tunali
dc.date.accessioned2024-04-24T17:48:07Z
dc.date.available2024-04-24T17:48:07Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn Crimean-Congo Hemorrhagic Fever (CCHF), the main target of the virus is endothelial cells, monocytes and hepatocytes. The virus in these cells leads to the development of capillary vessels dysfunction, which induces clinical and pathological changes during the disease. Increase in capillary permeability and coagulation dysfunction constitute a tendency to bleed. In the current study, we aimed to investigate the relationship between VKORC1 and bleeding tendency in CCHF. Forty-eight consecutive patients with a laboratory-confirmed diagnosis of CCHF were treated with blood products, and 37 healthy volunteers as the control group were prospectively enrolled into the study. The DNA was obtained from each sample using PCR amplification method, and VKORC1 1639 G>A gene polymorphisms were scanned in the DNA samples. In CCHF group of patients with bleeding VKORC1 gene were analyzed. Normal genotype was detected in 5 (22.7%) patients, homozygote mutation was detected in 2 (9.1%) patients and heterozygote mutation was detected in 15 (68.2%) patients, respectively. Furthermore, the G allele frequency was statistically higher in study group (51 [53%] vs. 27 [36%]) (p<0.005). It seems to be that VKORC1 gene A allele frequencies saliently higher in CCHF. This might be associated with increased bleeding risk in CCHF. Analyzing of VKORC1 gene polymorphisms could help in the risk stratification of patients with CCHF.en_US
dc.identifier.endpage420en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue3en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://hdl.handle.net/11468/22891
dc.identifier.volume24en_US
dc.identifier.wosWOS:000322308100021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-India
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean-Congo Hemorrhagic Feveren_US
dc.subjectVkorc1 Geneen_US
dc.subjectBleedingen_US
dc.subjectRisk Stratificationen_US
dc.titleThe VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo Hemorrhagic Fever patients.en_US
dc.titleThe VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo Hemorrhagic Fever patients.
dc.typeArticleen_US

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