In silico and in vitro evaluation of oxypeucedanin-induced anticancer activity: Mitotoxicity?

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dc.contributor.authorErgüç, Ali
dc.contributor.authorOkur, Hayati
dc.contributor.authorKarakuş, Fuat
dc.contributor.authorAlbayrak, Gökay
dc.contributor.authorArzuk, Ege
dc.contributor.authorBaykan, Şüra
dc.date.accessioned2025-02-22T14:17:56Z
dc.date.available2025-02-22T14:17:56Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: This study aims to evaluate the alterations in Oxypeucedanin (OXY)-mediated anticancer activity in different media. Second aim is to predict the affinity of OXY to electron transfer chain (ETC) complexes. Materials and Methods: MTT and LDH leakage assays were performed with OXY. Molecular docking studies were also conducted to predict the affinity of OXY to ETC complexes. Results: 250 µM OXY reduced viability in glucose media. ≥50 µM OXY decreased viability in galactose media. ≥50 µM OXY increased membrane disruption in galactose media. Molecular docking studies also showed that OXY might possess the capacity to bind to the inhibition sites of Complex I and IV. Conclusion: Galactose-conditioned media exacerbated the OXY-mediated cytotoxicity. Preliminary results suggested that mitotoxicity might take part in anticancer activity. Furthermore, OXY might cause ETC dysfunctions due to selective inhibition of Complex I and IV.en_US
dc.identifier.doi10.30569/adiyamansaglik.1325975
dc.identifier.endpage161en_US
dc.identifier.issn2458-9179
dc.identifier.issue3en_US
dc.identifier.startpage153en_US
dc.identifier.trdizinid1231556en_US
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1325975
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1231556
dc.identifier.urihttps://hdl.handle.net/11468/30122
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectAnticancer activityen_US
dc.subjectIn silicoen_US
dc.subjectOxypeucedaninen_US
dc.subjectMitotoxicityen_US
dc.titleIn silico and in vitro evaluation of oxypeucedanin-induced anticancer activity: Mitotoxicity?en_US
dc.typeArticleen_US

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