Effects on Gingiva of Diabetes Mellitus Induced by Streptozotocin in Rats

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dc.contributor.authorIpek, Fikret
dc.date.accessioned2024-04-24T17:44:51Z
dc.date.available2024-04-24T17:44:51Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the histopathological alterations in gingival tissue of streptozotocin (STZ) diabetic rats and the expressions of ADAMTS-5 and TNF-alpha to better understand the effects of diabetes on oral mucosa. STUDY DESIGN: Twenty Wistar rats, divided into control and diabetic groups, received a single dose of STZ (55 mg/kg) ip. The rats were sacrificed, and gingival tissues were dissected and fixed in formalin for routine paraffin protocol. Hematoxylin-eosin and immunohistochemical staining (ADAMTS-5 and TNF-alpha) were applied and sections were examined under a microscope. RESULTS: The control group revealed regular placement of epithelial cells. In the diabetic group significant thinning of the epithelial cell layer, degeneration of the cells in the papillary region, pyknosis in nuclei, and inflammatory cell infiltration were seen. Negative ADAMTS-5 expression was observed in parakeratinized epithelium of the control group. The diabetic group showed positive ADAMTS-5 expression in the epithelial cells. In the control group, TNF-alpha positive expression was observed in some of the gingival epithelial and vascular endothelial cells. In the diabetic group, TNF-alpha expression was observed in basal lamina, endothelial cells, and fibroblast cells and dilated blood vessels. CONCLUSION: In diabetics, hypertrophic changes of the gingival epithelium with the epithelial permeability alteration and the presence of intraepithelial inflammatory cells eventually gave rise to degenerative lesions and epithelial ulceration.en_US
dc.identifier.endpage22en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/11468/22317
dc.identifier.volume42en_US
dc.identifier.wosWOS:000531823600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdamts-5en_US
dc.subjectDental Cariesen_US
dc.subjectDental Health Surveysen_US
dc.subjectDiabetesen_US
dc.subjectDiabetes Complicationsen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectGingivaen_US
dc.subjectHistopathologyen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMouth Mucosaen_US
dc.subjectOral Healthen_US
dc.subjectPeriodontal Diseasesen_US
dc.subjectTnf-Alphaen_US
dc.titleEffects on Gingiva of Diabetes Mellitus Induced by Streptozotocin in Ratsen_US
dc.titleEffects on Gingiva of Diabetes Mellitus Induced by Streptozotocin in Rats
dc.typeArticleen_US

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