Inhibitors in hemophilia A and B in Southeast of Turkey

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dc.contributor.authorAltintaş A.
dc.contributor.authorAyyildiz O.
dc.contributor.authorÇil T.
dc.contributor.authorSöker M.
dc.contributor.authorMüftüoğlu E.
dc.date.accessioned2024-04-24T18:43:39Z
dc.date.available2024-04-24T18:43:39Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractHemophilia A and B are inherited, X chromosome linked coagulation disorders that characterized by clinical signs and symptoms seen in males. The most important treatment related complication was viral infection in the past years, but this problem is overcoming by developing of modern factors concentrate which are available in the market, nowadays. However, developing inhibitor against concentrated factors that used is the most important problem, as in western countries. In this study, we aimed to evaluate the inhibitor developing rate in 73 hemophiliac pediatric and adult patients who have treated and followed up in Dicle University hematology polyclinics in Southeastern Anatolia. 62 (85%) of cases were hemophilia A and 11 (15%) were hemophilia B. Of hemophilia A patients 41 (66.2%) had severe and 17 (27.4%) had moderate disease. The same rates were 7 (63.6%) and 3 (27.3%) in hemophilia B patients, respectively. Only one patient (2.4%) with severe hemophilia A had high titrate of inhibitor positivity (17 BU/ml). Inhibitor was present in any of hemophilia B patients. This rate was lower than previously reported data from community of Turkey. We proposed that the most important cause of this low frequency of inhibitor is using fresh frosen plasma in treatment of those patients with bleeding.en_US
dc.identifier.endpage132en_US
dc.identifier.issn1306-133X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33750009376en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/11468/24247
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofUHOD - Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBethesda Testen_US
dc.subjectHemophiliaen_US
dc.subjectInhibitoren_US
dc.titleInhibitors in hemophilia A and B in Southeast of Turkeyen_US
dc.title.alternativeGüneydoğu anadolu bölgesi hemofili hastalarinda inhibitör sorunuen_US
dc.typeArticleen_US

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