Investigation of the Sox-9 and Cited-1 Immune Activity in Placentas of Women with Placenta Accreta

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dc.contributor.authorAkalın, Senem
dc.contributor.authorÖcal, Ece
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-03-08T18:29:12Z
dc.date.available2025-03-08T18:29:12Z
dc.date.issued2023
dc.departmentDicle Üniversitesi
dc.description.abstractAim: In this study, we investigated the immune activity of the Sox-9 and Cited-1 in women with placenta accreta. Material and Methods: 20 healthy and 20 placenta accreta were processed for routine histological tissue processing. Placentals samples were dissected and fixed in 10% formaldehyde solution. Samples were embedded in paraffin blocks. Clinical and biochemical parameters were recorded. Placental sections were cut from paraffin blocks and stained with Sox-9 and Cited-1 immunostaining. Results: In our study, control group showed negative Cited-1 expression in decidual cells, root villi and connective tissue areas in general. Placenta accreta group showed increased Cited-1 expression in degenerated decidual cells, fibroblastic cells and endothelium. In control group, Sox-9 expression was negative in the syncytial knots, in the vascular endothelial cells. In placenta accreta group, Sox-9 reaction was positive in the root villi, in the blood vessels, in the connective tissue. Conclusion: It was observed that the Sox-9 reaction was increased and inflammation was induced, depending on the differences in decidual cells, in the syncytial area and in the vascular endothelium in in placentas of women with placenta accreta. It is thought that Sox-9 signaling processes are being determined and Cited-1 may be stimulants that affect cell proliferation and angiogenesis regulation and affect placental development.
dc.identifier.doi10.37990/medr.1239182
dc.identifier.endpage6
dc.identifier.issn2687-4555
dc.identifier.issue2
dc.identifier.startpage332
dc.identifier.urihttps://doi.org/10.37990/medr.1239182
dc.identifier.urihttps://hdl.handle.net/11468/31717
dc.identifier.volume5
dc.language.isoen
dc.publisherTıbbi Kayıtlar Derneği
dc.relation.ispartofMedical Records
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectplacenta accreta
dc.subjectPlacenta accreta
dc.subjectSox-9
dc.subjectCited-1
dc.subjectimmunostaining
dc.titleInvestigation of the Sox-9 and Cited-1 Immune Activity in Placentas of Women with Placenta Accreta
dc.typeArticle

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