Preparation, Characterization and Drug Release of Chitosan Hydrogels Derived From Substituted Salicylaldehyde

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dc.authoridEVCIL, MURAT/0000-0002-4646-8042
dc.contributor.authorEvcil, Murat
dc.contributor.authorKarakaplan, Mehmet
dc.date.accessioned2025-02-22T14:09:08Z
dc.date.available2025-02-22T14:09:08Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractChitosan-based hydrogels (CSAD1, CSAD2 and CSAD3) have been successfully prepared by dynamic imine reaction between chitosan and varying ratios of 2-[(2,3-dihydroxy)-1-propoxy]benzaldehyde (SAD) as a linker group respectively. SAD was synthesized from salicylaldehyde and glycidol by atom economy method. FT-IR and NMR data were used to determine the SAD and hydrogels' structures. The fabricated hydrogels exhibit a porous structure that the pore size decreased with increasing ratio of SAD group. Hydrogels were swelled in aqueous media but not soluble in both acidic and alkaline medium. The highest swelling capacity was obtained at pH 7 with the order of CSAD1, CSAD2, and CSAD3, respectively. The high thermal behavior of the hydrogels was tested by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Ibuprofen was selected as a model drug for the drug release behaviors of the hydrogels. Release of ibuprofen is influenced by the pore sizes of the hydrogels in order of CSAD1, CSAD2, and CSAD3, respectively.en_US
dc.description.sponsorshipResearch Council of Dicle University (DUBAP) [FEN.19.009]en_US
dc.description.sponsorshipWe thank to Research Council of Dicle University (DUEBAP) for their financial support (Pr. Number: FEN.19.009), and thank to Science and Technique Research and Application Center of Dicle University (DUEBTAM) for their technical assistance.en_US
dc.identifier.doi10.1002/slct.202204426
dc.identifier.issn2365-6549
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202204426
dc.identifier.urihttps://hdl.handle.net/11468/29810
dc.identifier.volume8en_US
dc.identifier.wosWOS:000953724300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectChitosanen_US
dc.subjectSalicylaldehydeen_US
dc.subjectHydrogelsen_US
dc.subjectSwellingen_US
dc.subjectDrug deliveryen_US
dc.subjectSchiff basesen_US
dc.titlePreparation, Characterization and Drug Release of Chitosan Hydrogels Derived From Substituted Salicylaldehydeen_US
dc.typeArticleen_US

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