The Effect of Dimethyl Sulfoxide on Chromosomal Abnormalities in Human Peripheral Blood Lymphocytes

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dc.contributor.authorYücel, İlyas
dc.contributor.authorBinici, Mahir
dc.contributor.authorKavak, Fikriye Fulya
dc.contributor.authorOral, Diclehan
dc.contributor.authorTekeş, Selahattin
dc.contributor.authorBalkan, Mahmut
dc.date.accessioned2025-03-08T18:27:46Z
dc.date.available2025-03-08T18:27:46Z
dc.date.issued2020
dc.departmentDicle Üniversitesi
dc.description.abstractObjective: The main aim of this study was to examine the effects of dimethyl sulfoxide (DMSO) on chromosomal abnormalities in human peripheral blood lymphocytes. Methods: Peripheral blood samples were collected from two healthy men and two healthy women. Then, in vitro studies were conducted with these blood samples , and the results were cytogenetically analyzed . There were two groups: a DMSO group and a control group. DMSO and control medium were added to the samples at 24 hours and 48 hours. Results: A total of 800 metaphases were examined in this study. Depending on the increase in the number of groups and the time of application, an increase in chromosomal abnormalities was observed, and these were recorded. Conclusion: In many previous studies, the effects of DMSO have been examined in various tissues and the body, but there are fewer studies about the effects on chromosomes. In this study, we researched the effects of DMSO, except for negative effects and toxicity, on chromosomal abnormalities.
dc.identifier.issn2146-6033
dc.identifier.issn2146-6033
dc.identifier.issue2
dc.identifier.startpage42186
dc.identifier.urihttps://hdl.handle.net/11468/31204
dc.identifier.volume12
dc.language.isoen
dc.publisherVeysi AKPOLAT
dc.relation.ispartofInternational Archives of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectDMSO
dc.subjectCytogenetics
dc.subjectChromosomal abnormality
dc.titleThe Effect of Dimethyl Sulfoxide on Chromosomal Abnormalities in Human Peripheral Blood Lymphocytes
dc.typeArticle

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