Serum resistin levels and metabolic changes in bipolar disorder

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dc.contributor.authorYumru, Mehmet
dc.contributor.authorGergerlioglu, H. Serdar
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorBasarali, Kemal
dc.contributor.authorKalenderoglu, Aysun
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2024-04-24T17:27:39Z
dc.date.available2024-04-24T17:27:39Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Metabolic changes in bipolar disorder appear to be among the cluster of disturbances that have insulin resistance as a common etiologic factor. Several recently discovered adipokines such as resistin and visfatin play a role in the pathogenesis of insulin resistance. In this study we aimed to evaluate the association between serum resistin levels and metabolic changes in bipolar disorder. Method: Sixty euthymic bipolar I disorder patients, of 29 on mood stabilizer (MS) (lithium, valproic acid, carbamazepine, and lamotrigine) treatment and of 31 on atypical antipsychotic (AA) (risperidone, quetiapine and olanzapine) treatment for at least 3 months, were enrolled. The control group consisted of 27 healthy members who have had similar distributions of age, sex, and BMI with the patients. Resistin, glucose, triglycerides, and high density lipoprotein (HDL) levels were measured in all groups. Results: Resistin levels were found to be significantly high in bipolar patients than that in the controls. However, when metabolic parameters were considered resistin levels were not significantly different between the patient and control groups (p>0.05). Conclusion: Despite serum resistin levels were high in bipolar patients, we did not find any association between metabolic disturbances and treatment modalities.en_US
dc.identifier.doi10.5455/jmood.20120516040842
dc.identifier.endpage50en_US
dc.identifier.issn2146-1473
dc.identifier.issn2146-2380
dc.identifier.issue2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.5455/jmood.20120516040842
dc.identifier.urihttps://hdl.handle.net/11468/20122
dc.identifier.volume2en_US
dc.identifier.wosWOS:000218923000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofJournal of Mood Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectResistinen_US
dc.subjectMetabolic Changesen_US
dc.titleSerum resistin levels and metabolic changes in bipolar disorderen_US
dc.titleSerum resistin levels and metabolic changes in bipolar disorder
dc.typeArticleen_US

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