Synthesis, characterization and biological evaluation of esterderivatives of 4-(diethylamino) salicylaldehyde cholinesterase and tyrosinase inhibitors

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dc.authorid0000-0003-0401-7419en_US
dc.authorid0000-0003-0419-7798en_US
dc.authorid0000-0002-7840-5919en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorÇakmak, Reşit
dc.contributor.authorÇınar, Ercan
dc.contributor.authorBaşaran, Eyüp
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2023-08-01T12:34:25Z
dc.date.available2023-08-01T12:34:25Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractAlzheimer's disease, one of the diseases that still has no a specific therapy, has become amajor public health issue owing to the increasing population of the elderly, particularly in richcountries. Inhibitory of cholinesterase enzymes (acetylcholinesterase (AChE) and butyrylcholinesterase(BChE), which hydrolyze acetylcholine (ACh) and butyrylcholine (BCh) neurotransmitters, haverecently become a choice for the therapy of this disease. Therefore, there is currently a great demandfor novel enzyme inhibitors with desirable properties for applying in the treatment of AD. In this study,a series of ester derivatives of 4-(diethylamino)salicylaldehyde (1-5) were successfully prepared andstructurally illuminated with FT-IR, 1H- and 13C NMR spectroscopy. The inhibitory properties of thesynthesized molecules on AChE, BChE, and tyrosinase enzymes were investigated, respectively.Compound 1 indicated potent inhibitory activity against BChE with 87.28±0.87% inhibition better thangalanthamine (73.83±0.25 %inhibition) employed as standard. Compound 3 showed significantinhibitory effect against tyrosinase with 87.73±0.22 % inhibition, which is better than kojic acid utilizedas standard. The obtained results clearly revealed that some of these molecules have the potential to be used as potent enzyme inhibitor candidates in the future studies.en_US
dc.identifier.citationÇakmak, R., Çınar, E., Başaran, E. ve Boğa, M. (2021). Synthesis, characterization and biological evaluation of esterderivatives of 4-(diethylamino) salicylaldehyde cholinesterase and tyrosinase inhibitors. Middle East Journal of Science, 7(2), 137-144.en_US
dc.identifier.doi10.51477/mejs.947973
dc.identifier.endpage144en_US
dc.identifier.issn2618-6136
dc.identifier.issue2en_US
dc.identifier.startpage137en_US
dc.identifier.trdizinid507519
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/507519
dc.identifier.urihttps://hdl.handle.net/11468/12386
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/507519
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherINESEG Yayıncılıken_US
dc.relation.ispartofMiddle East Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEstersen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectTyrosinaseen_US
dc.titleSynthesis, characterization and biological evaluation of esterderivatives of 4-(diethylamino) salicylaldehyde cholinesterase and tyrosinase inhibitorsen_US
dc.titleSynthesis, characterization and biological evaluation of esterderivatives of 4-(diethylamino) salicylaldehyde cholinesterase and tyrosinase inhibitors
dc.typeArticleen_US

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