Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study

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dc.contributor.authorAraç, Songül
dc.contributor.authorKarahan, Mehmet Zülkif
dc.contributor.authorÖzel, Mehmet
dc.contributor.authorYiğit, Ramazan
dc.contributor.authorAkkoç, Hasan
dc.contributor.authorAraç, Eşref
dc.date.accessioned2025-03-08T18:28:55Z
dc.date.available2025-03-08T18:28:55Z
dc.date.issued2021
dc.departmentDicle Üniversitesi
dc.description.abstractBackground/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ. Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (P
dc.identifier.doi10.28982/josam.843042
dc.identifier.endpage416
dc.identifier.issn2602-2079
dc.identifier.issue5
dc.identifier.startpage412
dc.identifier.urihttps://doi.org/10.28982/josam.843042
dc.identifier.urihttps://hdl.handle.net/11468/31526
dc.identifier.volume5
dc.language.isoen
dc.publisherSelçuk BAŞAK
dc.relation.ispartofJournal of Surgery and Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectCOVID-19
dc.subjectHydroxychloroquine
dc.subjectAzithromycin
dc.subjectECG
dc.subjectiCEB
dc.subjectTp-e interval
dc.titleEffects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study
dc.typeArticle

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