Fetal Loss in a Patient with Acute Myeloblastic Leukemia Associated with FLAG-IDA Regime

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dc.contributor.authorPasa, Semir
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorCil, Timucin
dc.contributor.authorAyyildiz, Orhan
dc.date.accessioned2024-04-24T17:40:10Z
dc.date.available2024-04-24T17:40:10Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractAcute leukemia in pregnancy offers a unique management dilemma in the absence of clear guidelines. There is some transporters localized into the placental trophoblasts plays an important role in limiting the passage of substrate drug. Herein, we reported a case of fetal loss in a pregnant patient in 34 gestational weeks, with acute myeloblastic leukemia who treated with high dose cytarabine plus fludarabine chemotherapy, to discuss the effects of cytotoxic agent on fetus. There were many reports about pregnancies complicated with AML treated with standart dose cytosine arabinoside and antracyclin combination. We suggest that high dose chemotherapy, mainly FLAG-IDA regime may cause fetal death, although in nearby term periods. Understanding the role of drug transporters in moderating transplacental passage of substrates has important clinical implications for choosing specific drugs to achieve therapeutic objectives.en_US
dc.identifier.endpage112en_US
dc.identifier.issn1306-133X
dc.identifier.issue2en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://hdl.handle.net/11468/21648
dc.identifier.volume19en_US
dc.identifier.wosWOS:000271595500009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregnancyen_US
dc.subjectLeukemiaen_US
dc.subjectFludarabineen_US
dc.subjectHigh-Dose Chemotherapyen_US
dc.titleFetal Loss in a Patient with Acute Myeloblastic Leukemia Associated with FLAG-IDA Regimeen_US
dc.titleFetal Loss in a Patient with Acute Myeloblastic Leukemia Associated with FLAG-IDA Regime
dc.typeArticleen_US

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